Enantioselective Biocatalytic Reduction of Non-protected Hydroxyacetophenones

被引：5
作者：
Neupert, Adrian [1 ]
Ress, Tina [1 ]
Wittmann, Juergen [1 ]
Hummel, Werner [2 ]
Groeger, Harald [1 ]
机构：
[1] Univ Erlangen Nurnberg, Dept Chem & Pharm, D-91054 Erlangen, Germany
[2] Univ Dusseldorf, Forschungszentrum Julich, Inst Mol Enzyme Technol, D-52426 Julich, Germany
来源：
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES | 2010年 / 65卷 / 03期
关键词：
Alcohols; Asymmetric Synthesis; Biocatalysis; Enzymes; Reduction; ALCOHOL-DEHYDROGENASE; ASYMMETRIC REDUCTION; (S)-ALCOHOL DEHYDROGENASE; 2-STEP SYNTHESIS; COMBINATION; SUBSTRATE; EXPRESSION; KETONES; ACCESS;
D O I：
10.1515/znb-2010-0317
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Direct enantioselective reduction of 2'-, 3'- and 4'-hydroxyacetophenone without protection of the hydroxy moiety was carried out in the presence of (R)- and (S)-alcohol dehydrogenases as biocatalysts. Whereas reduction of 2'-hydroxyacetophenone gave only low to medium conversions, reduction of 3'- and 4'-hydroxyacetophenone proceeded efficiently leading to the resulting 1-(3-hydroxyphenyl)ethan-1 -ol and 1-(4-hydroxyphenypethan- 1-01 with high conversion (up to > 95%) and excellent enantioselectivity (up to > 99% cc).
引用
收藏
页码：337 / 340
页数：4
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