F2-isoprostanes and hepatic fibrosis

被引:0
作者
Comporti, M [1 ]
Arezzini, B [1 ]
Signorini, C [1 ]
Sgherri, C [1 ]
Vecchio, D [1 ]
Monaco, B [1 ]
Gardi, C [1 ]
机构
[1] Univ Siena, Dept Pathophysiol Expt Med & Publ Hlth, I-53100 Siena, Italy
来源
SFRR: PROCEEDINGS OF THE XII BIENNIAL MEETING OF THE SOCIETY FOR FREE RADICAL RESEARCH INTERNATIONAL | 2004年
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中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In a rat model of chronic CCl4 intoxication leading to fibrosis, plasma F-2-isoprostanes (Iso) were elevated for the entire experimental period and correlated to hepatic collagen content. HSC from normal liver were cultured up to activation and then treated for 48 h with Iso in the range of the concentrations found in the in vivo studies (10(-9)-10(-8) M). Iso induced marked increase in cell proliferation as well as increase in collagen synthesis. Total collagen content was similarly increased. Also, Iso markedly increased the production of TGF-beta 1 by the promonocytic human U937 cells, assumed as model of Kupffer cells or liver macrophages. Finally, in preliminary studies, Iso were found to be elevated in a small group of alcoholic patients. In conclusion, Iso generated by lipid peroxidation in hepatocytes may mediate the HSC proliferation and collagen hyperproduction seen in hepatic fibrosis.
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页码:267 / 272
页数:6
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