Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects

被引：142

作者：

Durduran, Turgut ^{[1
]}

Zhou, Chao ^{[2
]}

Buckley, Erin M. ^{[2
]}

Kim, Meeri N. ^{[2
]}

Yu, Guoqiang ^{[3
]}

Choe, Regine ^{[2
]}

Gaynor, J. William ^{[4
]}

Spray, Thomas L. ^{[4
]}

Durning, Suzanne M. ^{[5
]}

Mason, Stefanie E. ^{[6
]}

Montenegro, Lisa M. ^{[7
]}

Nicolson, Susan C. ^{[7
]}

Zimmerman, Robert A. ^{[8
]}

Putt, Mary E. ^{[9
]}

Wang, Jiongjiong ^{[10
]}

Greenberg, Joel H. ^{[11
]}

Detre, John A. ^{[10
,11
]}

Yodh, Arjun G. ^{[2
]}

Licht, Daniel J. ^{[6
,11
]}

机构：

[1] ICFO Inst Ciencies Foton, Castelldefels 08660, Spain

[2] Univ Penn, Dept Phys & Astron, Philadelphia, PA 19104 USA

[3] Univ Kentucky, Ctr Biomed Engn, Lexington, KY 40506 USA

[4] Childrens Hosp Philadelphia, Div Cardiothorac Surg, Philadelphia, PA 19104 USA

[5] Childrens Hosp Philadelphia, Div Resp Therapy, Philadelphia, PA 19104 USA

[6] Childrens Hosp Philadelphia, Div Neurol, Philadelphia, PA 19104 USA

[7] Childrens Hosp Philadelphia, Dept Anesthesiol & Crit Care, Philadelphia, PA 19104 USA

[8] Childrens Hosp Philadelphia, Div Neuroradiol, Philadelphia, PA 19104 USA

[9] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[10] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA

[11] Univ Penn, Dept Neurol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2010年 / 15卷 / 03期

关键词：

near-infrared spectroscopy; diffuse optics; diffuse correlation spectroscopy; congenital heart disease; pediatrics; cerebral blood flow; NEAR-INFRARED SPECTROSCOPY; CARBON-DIOXIDE REACTIVITY; DIFFUSE CORRELATION SPECTROSCOPY; BLOOD-FLOW; CARDIOPULMONARY BYPASS; PRETERM INFANTS; BRAIN-INJURY; ARTERIAL; PERFUSION; SATURATION;

D O I：

10.1117/1.3425884

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We employ a hybrid diffuse correlation spectroscopy (DCS) and near-infrared spectroscopy (NIRS) monitor for neonates with congenital heart disease (n=33). The NIRS-DCS device measured changes during hypercapnia of oxyhemoglobin, deoxyhemoglobin, and total hemoglobin concentrations; cerebral blood flow (rCBF(DCS)); and oxygen metabolism (rCMRO(2)). Concurrent measurements with arterial spin-labeled magnetic resonance imaging (rCBF(ASL-MRI), n=12) cross-validate rCBF(DCS) against rCBF(ASL-MRI), showing good agreement (R=0.7, p=0.01). The study demonstrates use of NIRS-DCS on a critically ill neonatal population, and the results indicate that the optical technology is a promising clinical method for monitoring this population. (C) 2010 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3425884]

引用

页数：10

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