Visible-Light-Induced Radical Cascade Cyclization: Synthesis of (20S)-Camptothecin, SN-38 and Irinotecan

被引：16

作者：

Yuan, Yao ^{[1
]}

Dong, Wuheng ^{[1
]}

Gao, Xiaoshuang ^{[1
]}

Xie, Xiaomin ^{[1
]}

Curran, Dennis P. ^{[2
]}

Zhang, Zhaoguo ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai Key Lab Mol Engn Chiral Drugs, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[2] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

来源：

CHINESE JOURNAL OF CHEMISTRY | 2018年 / 36卷 / 11期

基金：

中国国家自然科学基金;

关键词：

photocatalysis; radicals; camptothecin; irinotecan; SN-38; ruthenium; ASYMMETRIC-SYNTHESIS; ANTITUMOR AGENTS; CAMPTOTHECIN; ISONITRILES; (S)-CAMPTOTHECIN; CANCER;

D O I：

10.1002/cjoc.201800358

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(20S)-Camptothecin, irinotecan and SN-38 were successfully synthesized by a photocatalyzed radical cascade cyclization from an N-propargyl iodopyridinone and an arylisonitrile under visible light with a ruthenium catalyst. This synthetic method provided a useful entry into composing camptothecin family of antitumor agents in good yields under mild reaction conditions without the use of heavy metal reagents.

引用

页码：1035 / 1040

页数：6

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