A new 3-alkylpyridine alkaloid from the marine sponge Haliclona sp and its cytotoxic activity

被引：21

作者：

Zhang, Huawei ^{[1
,2
]}

Loveridge, Steven T. ^{[2
]}

Tenney, Karen ^{[2
]}

Crews, Phillip ^{[2
]}

机构：

[1] Zhejiang Univ Technol, Sch Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

[2] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 11期

关键词：

3-alkylpyridine; alkaloid; Haliclona sp; cytotoxicity; AMINO ACID MOIETY; PYRIDINE ALKALOIDS; CRIBROCHALINA SP; AMPHIMEDON SP; XESTOSPONGIA;

D O I：

10.1080/14786419.2015.1054826

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new alkaloid, 3-dodecyl pyridine containing a terminal cyano group (1), was isolated from the methanol extract of an Indonesia marine sponge Haliclona sp. Its chemical structure was determined by a combination of spectroscopic methods, including 1D and 2D NMR. Bioassay results indicated that compound 1 had moderate cytotoxity against tumour cell lines A549, MCF-7 and Hela with IC50 values of 41.8, 48.4 and 33.2 mu M, respectively.

引用

页码：1262 / 1265

页数：4

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