A self-assembled subphthalocyanine-based nanophotosensitiser for photodynamic therapy

被引：6

作者：

Casellas, Nicolas M. ^{[1
,2
,3
]}

Dai, Gaole ^{[4
]}

Xue, Evelyn Y. ^{[4
]}

Fonseca, Alba ^{[1
,2
]}

Ng, Dennis K. P. ^{[4
]}

Garcia-Iglesias, Miguel ^{[1
,2
,3
,5
]}

Torres, Tomas ^{[1
,2
,3
]}

机构：

[1] Univ Autonoma Madrid, Dept Organ Chem, Calle Francisco Tomas y Valiente 7, Madrid 28049, Spain

[2] Univ Autonoma Madrid, Inst Adv Res Chem Sci IadChem, Calle Francisco Tomas y Valiente 7, Madrid 28049, Spain

[3] IMDEA Nanociencia, C Faraday 9, Madrid 28049, Spain

[4] Chinese Univ Hong Kong, Dept Chem, Hong Kong, Peoples R China

[5] Univ Cantabria, QUIPRE Dept, Avd Los Castros 46, Santander 39005, Spain

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 05期

关键词：

PHOTOSENSITIZERS; DESIGN;

D O I：

10.1039/d1cc05977g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A subphthalocyanine substituted with nine tetra(ethylene glycol) chains on the periphery has been synthesised. This novel amphiphilic and cone-shaped compound can self-assemble in water into spherical nanoparticles with a hydrodynamic diameter of 154 nm. These nanoparticles can be taken up readily by cancer cells and localised predominately in lysosomes where they disassemble gradually, leading to activation in fluorescence emission and, photocytotoxicity, showing IC50 values of as low as 1.2 mu M.

引用

页码：669 / 672

页数：4

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