Insights from zebrafish on human pigment cell disease and treatment

被引：39
作者：
Cooper, Cynthia D. [1 ]
机构：
[1] Washington State Univ, Sch Mol Biosci, 14204 NE Salmon Creek Ave,VSCI 230, Vancouver, WA 98686 USA
来源：
DEVELOPMENTAL DYNAMICS | 2017年 / 246卷 / 11期
关键词：
melanocyte; melanophore; zebrafish; skin; chemoresistance; HERMANSKY-PUDLAK SYNDROME; NEURAL-CREST; MELANOMA-CELLS; C-KIT; TRANSCRIPTIONAL REGULATION; MELANOPHORE DEVELOPMENT; MULTIDRUG-RESISTANCE; DANIO-RERIO; IN-VIVO; MITF;
D O I：
10.1002/dvdy.24550
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Black pigment cells, melanocytes, arise early during development from multipotent neural crest cells. Melanocytes protect human skin from DNA damaging sunrays and provide color for hair, eyes, and skin. Several disorders and diseases originate from these cells, including the deadliest skin cell cancer, melanoma. Thus, melanocytes are critical for a healthy life and for protecting humans from disease. Due to the ease of visualizing pigment cells through transparent larvae skin and conserved roles for zebrafish melanophore genes to mammalian melanocyte genes, zebrafish larvae offer a biologically relevant model for understanding pigment cell development and disease in humans. This review discusses our current knowledge of melanophore biology and how zebrafish are contributing to improving how diseases of melanocytes are understood and treated in humans. Developmental Dynamics 246:889-896, 2017. (c) 2017 Wiley Periodicals, Inc.
引用
收藏
页码：889 / 896
页数：8
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