Exploring chemical diversity of epoxyquinoid natural products: Synthesis and biological activity of (-)-jesterone and related molecules

被引：78

作者：

Hu, YB

Li, CM

Kulkarni, BA

Strobel, G

Lobkovsky, E

Torczynski, RM

Porco, JA

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Ctr Streamlined Synth, Metcalf Ctr Sci & Engn, Boston, MA 02215 USA

[3] Montana State Univ, Dept Plant Sci, Bozeman, MT 59717 USA

[4] Cornell Univ, Baker Lab, Dept Chem, Ithaca, NY 14853 USA

[5] Cytoclonal Pharmaceut Inc, Dallas, TX 75235 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 11期

关键词：

D O I：

10.1021/ol0159367

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Enantioselective syntheses of the potent antifungal agent (-)-jesterone, its hydroxy epimer, and a dimeric quinone epoxide derivative are reported. The synthesis involves diastereoselective epoxidation of a chiral quinone monoketal derivative and regio and stereoselective reduction of a quinone epoxide intermediate.

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页码：1649 / 1652

页数：4

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