A novel cationic copper(II) Schiff base complex: Synthesis, characterization, crystal structure, electrochemical evaluation, anti-cancer activity, and preparation of its metal oxide nanoparticles

被引：70

作者：

Ebrahimipour, S. Yousef ^{[1
]}

Sheikhshoaie, Iran ^{[1
]}

Castro, Jesus ^{[2
]}

Haase, Wolfgang ^{[3
]}

Mohamadi, Maryam ^{[1
,4
]}

Foro, Sabine ^{[5
]}

Sheikhshoaie, Mahdie ^{[1
]}

Esmaeili-Mahani, Saeed ^{[6
]}

机构：

[1] Shahid Bahonar Univ Kerman, Dept Chem, Fac Sci, Kerman 7616914111, Iran

[2] Univ Vigo, Fac Quim, Dept Quim Inorgan, Vigo 36310, Galicia, Spain

[3] Tech Univ Darmstadt, Eduard Zintl Inst Inorgan & Phys Chem, D-64287 Darmstadt, Germany

[4] PNU, Dept Chem, Tehran 193954697, Iran

[5] Dept Mat Sci, D-64287 Darmstadt, Germany

[6] Shahid Bahonar Univ Kerman, Fac Sci, Dept Biol, Kerman 7616914111, Iran

来源：

INORGANICA CHIMICA ACTA | 2015年 / 430卷

关键词：

Schiff base ONO ligand; Copper(II) complex; Cell viability; Electrochemical behavior; X-ray diffraction; X-RAY CRYSTAL; DFT CALCULATION; DNA-BINDING; MOLECULAR-STRUCTURES; CUO NANOPARTICLES; N-SALICYLIDENEAROYLHYDRAZINES; ANTIMICROBIAL ACTIVITY; PROTEIN-BINDING; GREEN SYNTHESIS; NLO BEHAVIOR;

D O I：

10.1016/j.ica.2015.03.016

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A tridentate ONO ligand (E)-N'-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide [HL] and its cationic Cu(II) complex [Cu(L)(H2O)]NO3 were synthesized and characterized by means of elemental analysis, FT-IR and UV-Vis spectrometry and conductivity measurements. The structure of the complex was determined using single crystal X-ray diffraction. The obtained data revealed that the Cu(II) center is coordinated by two oxygens and one nitrogen of the ligand. The fourth position is occupied by oxygen atom of a coordinated water molecule. X-ray data obtained showed that this complex possessed distorted square planar geometry around Cu(II) ion. Nitrate anion as the counter ion occupied the second sphere around the Cu(II) center via hydrogen bonding. The electrochemical behavior of the free ligand and its Cu(II) complex were studied using cyclic voltammetry. Nanoparticles (NPs) of CuO with the average size of 23 nm were prepared with thermal decomposition of the title complex and then were characterized using X-ray powder diffraction (XRD). Anti-cancer activities of the title compounds against human breast cancer (MCF-7 cells viability) were investigated and compared with each other. It was found that [Cu(L)(H2O)]NO3 complex showed higher anticancer activity than the others. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：245 / 252

页数：8

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