Pathology of hepatocellular carcinoma

被引：1
作者：
Longerich, Thomas [1 ]
Schirmacher, Peter [1 ]
机构：
[1] Heidelberg Univ, Pathol Inst, Univ Klinikum Heidelberg, Neuenheimer Feld 224, D-69120 Heidelberg, Germany
来源：
PATHOLOGE | 2022年 / 43卷 / 01期
关键词：
Liver cancer; Liver biopsy; Histology; Hepatocarcinogenesis; Molecular pathology; GLUTAMINE-SYNTHETASE; DOUBLE-BLIND; EXPRESSION; DIAGNOSIS; SORAFENIB; HSP70; IDENTIFICATION; GLYPICAN-3; INVASION; SUBTYPE;
D O I：
10.1007/s00292-021-01038-0
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related mortality worldwide and has a well-defined etiology. It develops in a stepwise process with morphologically defined precursor lesions. Typing of highly differentiated hepatocellular tumors is supported by immunohistological marker panel and the so-called matrix diagnosis. The recent World Health Organization (WHO) classification defined morpho-molecular HCC subtypes showing typical clinical and prognostic characteristics. If HCC subtyping is considered in future clinical studies of advanced HCC, this could help to introduce personalized HCC therapy. Currently, precision oncology is not available for HCC.
引用
收藏
页码：67 / 78
页数：12
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