Colorectal cancer risk and nitrate exposure through drinking water and diet

被引：111

作者：

Espejo-Herrera, Nadia ^{[1
,2
,3
]}

Gracia-Lavedan, Esther ^{[1
,2
,3
]}

Boldo, Elena ^{[3
,4
,5
]}

Aragones, Nuria ^{[3
,4
,5
]}

Perez-Gomez, Beatriz ^{[3
,4
,5
]}

Pollan, Marina ^{[3
,4
,5
]}

Molina, Antonio J. ^{[6
]}

Fernandez, Tania ^{[6
]}

Martin, Vicente ^{[3
,6
]}

La Vecchia, Carlo ^{[7
]}

Bosetti, Cristina ^{[8
]}

Tavani, Alessandra ^{[8
]}

Polesel, Jerry ^{[9
]}

Serraino, Diego ^{[9
]}

Gomez Acebo, Ines ^{[3
,10
]}

Altzibar, Jone M. ^{[3
,11
,12
]}

Ardanaz, Eva ^{[3
,13
]}

Burgui, Rosana ^{[3
,13
]}

Pisa, Federica ^{[14
]}

Fernandez-Tardon, Guillermo ^{[3
,15
]}

Tardon, Adonina ^{[3
,15
]}

Peiro, Rosana ^{[3
,16
]}

Navarro, Carmen ^{[3
,17
,18
]}

Castano-Vinyals, Gemma ^{[1
,2
,3
,19
]}

Moreno, Victor ^{[3
,20
,21
]}

Righi, Elena ^{[22
]}

Aggazzotti, Gabriella ^{[22
]}

Basagana, Xavier ^{[1
,2
,3
,19
]}

Nieuwenhuijsen, Mark ^{[1
,2
,3
,19
]}

Kogevinas, Manolis ^{[1
,2
,3
,19
]}

Villanueva, Cristina M. ^{[1
,2
,3
,19
]}

机构：

[1] Ctr Res Environm Epidemiol CREAL, ISGlobal, Doctor Aiguader 88, Barcelona 08003, Spain

[2] Univ Pompeii Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain

[3] CIBER Epidemiol & Salud PuL CIBERESP, Madrid, Spain

[4] Carlos III Inst Hlth, Natl Ctr Epidemiol, Canc & Environm Epidemiol Unit, Madrid, Spain

[5] IIS Puerta Hiero, Oncol & Hematol Area, Canc Epidemiol Res Grp, Madrid, Spain

[6] Univ Leon, Res Grp Gene Environm Interact & Hlth, E-24071 Leon, Spain

[7] Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy

[8] IRCCS Ist Ric Farmacol Mario Negri, Dept Epidemiol, Milan, Italy

[9] CRO Aviano Natl Canc Inst, IRCCS, Unit Epidemiol & Biostat, Aviano, Italy

[10] Univ Cantabria, IDIVAL, E-39005 Santander, Spain

[11] Publ Hlth Div Gipuzkoa, San Sebastian, Spain

[12] Biodonostia Res Inst, San Sebastian, Spain

[13] Navarra Publ Hlth Inst, Pamplona, Spain

[14] Azienda Osped Univ, SOC Igiene & Epidemiol Cin, Udipe, Italy

[15] Univ Oviedo, Oncol Inst IUOPA, Asturias, Spain

[16] Ctr Res Publ Hlth, Valencia, Spain

[17] Murcia Reg Hlth Council, Dept Epidemiol IMIB Arrixaca, Murcia, Spain

[18] Univ Murcia, Dept Hlth & Social Sci, Murcia, Spain

[19] IMIM Hosp Mar Med Res Inst, Barcelona, Spain

[20] Bellvitge Biomed Res Inst IDIBELL, Catalan Inst Oncol, Barcelona, Spain

[21] Univ Barcelona, Barcelona, Spain

[22] Univ Modena & Reggio Emilia, Modena, Italy

来源：

INTERNATIONAL JOURNAL OF CANCER | 2016年 / 139卷 / 02期

关键词：

colorectal cancer; nitrate; drinking water; diet; case-control studies; FOOD-FREQUENCY QUESTIONNAIRE; DISINFECTION BY-PRODUCTS; N-NITROSO COMPOUNDS; MUNICIPAL; SUPPLIES; VALIDATION; NITRITES; TUMORS; WOMEN; COLON;

D O I：

10.1002/ijc.30083

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ingesfed nitrate leads to the endogenous synthesis of N-nitroso compounds (NOCs), animal carcinogens with limited human evidence. We aimed to evaluate the risk of colorectal cancer (CRC) associated with nitrate exposure in drinking water and diet. A case-control study in Spain and Italy during 2008-2013 was conducted. Hospital-based incident cases and population based (Spain) or hospital-based (Italy) controls were interviewed on residential history, water consumption since age 18, and dietary information. Long-term waterborne ingested nitrate was derived from routine monitoring;records, linked to subjects residential histories and water consumption habits. Dietary nitrate intake was estimated from food frequency questionnaires and published food composition databases. Odd ratios (OR) were calculated using mixed models with area as random effect adjusted for CRC risk factors and other covariables. Generalized additive models (GAMS) were used to analyze exposure-response relationship. Interaction with endogenous nitrosation factors and other covariables was also evaluated. In total

引用

页码：334 / 346

页数：13

共 42 条

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