A human RNA polymerase II complex associated with SRB and DNA-repair proteins

被引：313

作者：

Maldonado, E

Shiekhattar, R

Sheldon, M

Cho, H

Drapkin, R

Rickert, P

Lees, E

Anderson, CW

Linn, S

Reinberg, D

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT BIOCHEM,HOWARD HUGHES MED INST,PISCATAWAY,NJ 08854

[2] STANFORD UNIV,DNAX RES INST MOLEC & CELLULAR BIOL INC,DEPT CHEM,PALO ALTO,CA 94304

[3] BROOKHAVEN NATL LAB,DEPT BIOL,UPTON,NY 11973

[4] UNIV CALIF BERKELEY,DEPT BIOCHEM,BERKELEY,CA 94720

来源：

NATURE | 1996年 / 381卷 / 6577期

关键词：

D O I：

10.1038/381086a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

WE report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins(1-3). The complex contains transcriptional coactivators and increases the activation of transcription, In addition, some components of the RNA polymerase II complex participate in DNA repair.

引用

页码：86 / 89

页数：4

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