Palladium-catalyzed direct construction of oxazoline-containing polycyclic scaffolds via tandem addition/cyclization of nitriles and arylboronic acids

被引：3

作者：

Cui, Shu-Qiang ^{[1
]}

Cheng, Na ^{[1
]}

Ma, Qian-Qian ^{[1
]}

Wei, Zhong-Lin ^{[1
]}

Liao, Wei-Wei ^{[1
,2
]}

机构：

[1] Jilin Univ, Coll Chem, Dept Organ Chem, Changchun 130012, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2021年 / 9卷 / 01期

关键词：

C-H ADDITION; ARYL KETONES; PALLADIUM(II)-CATALYZED SYNTHESIS; ACTIVATION; ACCESS; CARBOPALLADATION; 3-ACYLINDOLES; INDOLES; ARENES;

D O I：

10.1039/d1qo01260f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient construction of oxazoline-containing polycyclic scaffolds is presented through a Pd-catalyzed addition/cyclization of (hetero)arene tethered O-acyl cyanohydrin units and arylboronic acids. Diverse oxazoline-containing polycyclic compounds can be prepared in good to high yields under mild reaction conditions. This method can be extended to prepare multi-substituted polycyclic heterocyclic compounds via a Pd-catalyzed addition/cyclization/arylation tandem sequence using arylboronic acid and different heteroarene scaffolds such as thiophene, pyrrole and furan analogues.

引用

页码：123 / 128

页数：6

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