Cancer-associated transcription factors in DNA damage response

被引：11
|
作者：
Kciuk, Mateusz [1 ,2 ]
Gielecinska, Adrianna [1 ]
Kolat, Damian [3 ]
Kaluzinska, Zaneta [3 ]
Kontek, Renata [1 ]
机构：
[1] Univ Lodz, Dept Mol Biotechnol & Genet, Banacha 12-16, PL-90237 Lodz, Poland
[2] Univ Lodz, Doctoral Sch Exact & Nat Sci, Banacha St 12-16, PL-90237 Lodz, Poland
[3] Med Univ Lodz, Fac Med, Dept Expt Surg, Narutowicza 60, PL-90136 Lodz, Poland
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2022年 / 1877卷 / 04期
关键词：
Epithelial-mesenchymal transition (EMT); DNA damage response (DDR); DNA repair; Metastasis; Transcription factors (TFs); EPITHELIAL-MESENCHYMAL TRANSITION; EXCISION-REPAIR PROTEINS; FANCONI-ANEMIA PATHWAY; CELL-CYCLE; POLYMERASE THETA; C-MYC; DEPENDENT PHOSPHORYLATION; DIFFERENTIAL ROLES; REPLICATION STRESS; UP-REGULATION;
D O I：
10.1016/j.bbcan.2022.188757
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Transcription factors (TFs) constitute a wide and highly diverse group of proteins capable of controlling gene expression. Their roles in oncogenesis, tumor progression, and metastasis have been established, but recently their role in the DNA damage response pathway (DDR) has emerged. Many of them can affect elements of canonical DDR pathways, modulating their activity and deciding on the effectiveness of DNA repair. In this review, we focus on the latest reports on the effects of two TFs with dual roles in oncogenesis and metastasis (hypoxiainducible factor-1 alpha (HIF1 alpha), proto-oncogene MYC) and three epithelial-mesenchymal transition (EMT) TFs (twist-related protein 1 (TWIST), zinc-finger E-box binding homeobox 1 (ZEB1), and zinc finger protein 281 (ZNF281)) associated with control of canonical DDR pathways.
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页数：12
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