Assessment of Arterial Stiffness in Patients With Resistant Hypertension: Additional Insights Into the Pathophysiology of This Condition?

被引：16

作者：

Alsharari, Reem ^{[1
,2
,4
]}

Lip, Gregory Y. H. ^{[1
,2
,3
]}

Shantsila, Alena ^{[1
,2
]}

机构：

[1] Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England

[2] Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England

[3] Aalborg Univ, Dept Clin Med, Aalborg Thrombosis Res Unit, Aalborg, Denmark

[4] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Appl Med Sci, Cardiovasc Technol Dept, Riyadh, Saudi Arabia

来源：

AMERICAN JOURNAL OF HYPERTENSION | 2020年 / 33卷 / 02期

关键词：

arterial stiffness; augmentation index; blood pressure; high blood pressure; hypertension; pulse wave velocity; resistant hypertension; vascular function; vascular remodeling; EXPERT CONSENSUS DOCUMENT; PULSE-WAVE VELOCITY; LEFT ATRIAL SIZE; BLOOD-PRESSURE; AORTIC STIFFNESS; ENDOTHELIAL DYSFUNCTION; CARDIOVASCULAR EVENTS; INDEPENDENT PREDICTOR; DIABETES-MELLITUS; OUTCOME INCIDENCE;

D O I：

10.1093/ajh/hpz169

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

BACKGROUND Good understanding of the pathophysiological mechanism(s) of resistant hypertension (RH) and the relationship to vascular dysfunction is important for optimal blood pressure control. METHODS AND RESULTS The aim of this review article is to summarize the available data on the methods of arterial stiffness assessment, and their usefulness in RH. Several studies that provide information on the noninvasive methods of evaluation of arterial stiffness have been discussed; specifically, pulse wave velocity (PWV) and augmentation index (AIx) tests. Increased arterial stiffness, elevated AIx, and impaired endothelial function all act as indicators and predictors of cardiovascular events in patients with hypertension (HTN). CONCLUSION Our review suggests that PWV and AIx are impaired in patients with severe HTN. Early assessment of these characteristics can potentially be of value in patients with RH.

引用

页码：107 / 115

页数：9

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