Relationship Between Metabolites Composition and Biological Activities of Phyllanthus niruri Extracts Prepared by Different Drying Methods and Solvents Extraction

被引：29

作者：

Mediani, Ahmed ^{[1
]}

Abas, Faridah ^{[1
,2
]}

Khatib, Alfi ^{[3
]}

Tan, Chin Ping ^{[4
]}

Ismail, Intan Safinar ^{[2
,5
]}

Shaari, Khozirah ^{[2
,5
]}

Ismail, Amin ^{[6
]}

Lajis, N. H. ^{[7
]}

机构：

[1] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Sci, Serdang 43400, Selangor, Malaysia

[2] Univ Putra Malaysia, Inst Biosci, Lab Nat Prod, Serdang 43400, Selangor, Malaysia

[3] Int Islamic Univ Malaysia, Fac Pharm, Kuantan 25200, Pahang, Malaysia

[4] Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Technol, Serdang 43400, Selangor, Malaysia

[5] Univ Putra Malaysia, Fac Sci, Dept Chem, Serdang 43400, Selangor, Malaysia

[6] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Nutr & Dietet, Serdang 43400, Selangor, Malaysia

[7] Taibah Univ, Sci Chairs Unit, Al Moalim BinLaden Chair Sci Miracles Prophet Med, Al Munawarrah 41311, Saudi Arabia

来源：

PLANT FOODS FOR HUMAN NUTRITION | 2015年 / 70卷 / 02期

关键词：

alpha-Glucosidase inhibitory activity; Phyllanthus niruri; PLS; TPC; Antioxidant activity; ANTIOXIDANT ACTIVITY; ALPHA-GLUCOSIDASE; CONSTITUENTS; LEAVES; PHYTOCHEMICALS; INHIBITION; SEASON; PARTS;

D O I：

10.1007/s11130-015-0478-5

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The study investigated the changes in the metabolite, antioxidant and alpha-glucosidase inhibitory activities of Phyllanthus niruri after three drying treatments: air, freeze and oven dryings. Water extracts and extracts obtained using different solvent ratios of ethanol and methanol (50, 70, 80 and 100 %) were compared. The relationships among the antioxidant, alpha-glucosidase inhibitory activity and metabolite levels of the extracts were evaluated using partial least-square analysis (PLS). The solvent selectivity was assessed based on the phytochemical constituents present in the extract and their concentrations quantitatively analyzed using high performance liquid chromatography. The freeze-dried P. niruri samples that were extracted with the mixture of ethanol or methanol with low ratio of water showed higher biological activity values compared with the other extracts. The PLS results for the ethanolic with different ratio and water extracts demonstrated that phenolic acids (chlorogenic acid and ellagic acid) and flavonoids were highly linked to strong alpha-glucosidase inhibitory and antioxidant activities.

引用

页码：184 / 192

页数：9

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