ONX-0914, a selective inhibitor of immunoproteasome, ameliorates experimental autoimmune myasthenia gravis by modulating humoral response

被引：27

作者：

Liu, Ru-Tao ^{[1
]}

Zhang, Peng ^{[1
]}

Yang, Chun-Lin ^{[1
]}

Pang, Yu ^{[3
]}

Zhang, Min ^{[1
]}

Zhang, Na ^{[1
]}

Yue, Long-Tao ^{[2
]}

Li, Xiao-Li ^{[1
]}

Li, Heng ^{[1
]}

Duan, Rui-Sheng ^{[1
]}

机构：

[1] Shandong Univ, Shandong Prov Qianfoshan Hosp, Dept Neurol, Jinan 250014, Shandong, Peoples R China

[2] Shandong Univ, Shandong Prov Qianfoshan Hosp, Cent Lab, Jinan 250014, Shandong, Peoples R China

[3] Tar City Cent Hosp, Dept Pathol, Tai An 271000, Shandong, Peoples R China

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2017年 / 311卷

基金：

中国国家自然科学基金;

关键词：

ONX-0914; Immunoproteasome; Experimental autoimmune myasthenia gravis; Humoral immunity; SYSTEMIC-LUPUS-ERYTHEMATOSUS; FOLLICULAR HELPER-CELLS; DEPLETES PLASMA-CELLS; CENTER B-CELL; T-CELLS; GERMINAL CENTER; ACETYLCHOLINE-RECEPTOR; INTERFERON-GAMMA; IMMUNOGLOBULIN PRODUCTION; PROTEASOME INHIBITORS;

D O I：

10.1016/j.jneuroim.2017.08.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Accumulating evidence shows that the immunoproteasome participates in the immune response, beyond its initial role in the protein degradation. Here, we tested the effects of the selective immunoproteasome inhibitor, ONX-0914, on experimental autoimmune myasthenia gravis (EAMG). We found that ONX-0914 ameliorated the severity of ongoing EAMG by reducing the autoantibody affinity, accompanied with decreased Tfh cells and antigen presenting cells. Also it reduced the percentage of Th17 cells and inhibited the secretion of IL-17. Our data indicated ONX-0914 may bring benefit for MG therapy.

引用

页码：71 / 78

页数：8

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