SAR by HDX: Optimizing ligands for the estrogen receptor using hydrogen deuterium exchange (HDX) mass spectrometry

被引：0
|
作者：
Chalmers, Michael J. [1 ]
Wang, Yong [1 ]
Novick, Scott [2 ]
Griffin, Patrick R. [2 ]
Dodge, Jeffrey A. [1 ]
机构：
[1] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
[2] Scripps Res Inst, Dept Mol Therapeut, Jupiter, FL 33458 USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 248卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
519-MEDI
引用
收藏
页数：1
相关论文
共 50 条
  • [41] Hydrogen/Deuterium Exchange Mass Spectrometry for Weak Binders
    Hamuro, Yoshitomo
    Coales, Stephen J.
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2022, 33 (04) : 735 - 739
  • [42] Tutorial: Chemistry of Hydrogen/Deuterium Exchange Mass Spectrometry
    Hamuro, Yoshitomo
    JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 2021, 32 (01) : 133 - 151
  • [43] Receptor-binding hydrogen–deuterium exchange mass spectrometry as an additional measurement of biosimilarity
    Nicholas A. Treuheit
    Nicholas F. Crawford
    Steven Maki
    Jason Payne
    Jeff Allen
    Journal of Pharmaceutical Investigation, 2020, 50 : 413 - 423
  • [44] Combining Small-Molecule Bioconjugation and Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) to Expose Allostery: the Case of Human Cytochrome P450 3A4
    Ducharme, Julie
    Polic, Vanja
    Thibodeaux, Christopher J.
    Auclair, Karine
    ACS CHEMICAL BIOLOGY, 2021, 16 (05) : 882 - 890
  • [45] Covalent Modifier Discovery Using Hydrogen/Deuterium Exchange-Mass Spectrometry
    Kojima, Hiroyuki
    Yanagi, Ryota
    Higuchi, Eri
    Yoshizawa, Mami
    Shimodaira, Tomoyuki
    Kumagai, Misaki
    Kyoya, Tatsuhiro
    Sekine, Miyu
    Egawa, Daichi
    Ohashi, Nami
    Ishida, Hiroaki
    Yamamoto, Keiko
    Itoh, Toshimasa
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (07) : 4827 - 4839
  • [46] Recalibrating Protection Factors Using Millisecond Hydrogen/Deuterium Exchange Mass Spectrometry
    Stofella, Michele
    Seetaloo, Neeleema
    St John, Alexander N.
    Paci, Emanuele
    Phillips, Jonathan J.
    Sobott, Frank
    ANALYTICAL CHEMISTRY, 2025, 97 (05) : 2648 - 2657
  • [47] Hydrogen/deuterium exchange mass spectrometry analysis of protein aggregates
    Kheterpal, Indu
    Cook, Kelsey D.
    Wetzel, Ronald
    AMYLOID, PRIONS, AND OTHER PROTEIN AGGREGATES, PT C, 2006, 413 : 140 - 166
  • [48] Hydrogen/deuterium exchange mass spectrometry in the world of small molecules
    Damont, Annelaure
    Legrand, Anais
    Cao, Chenqin
    Fenaille, Francois
    Tabet, Jean-Claude
    MASS SPECTROMETRY REVIEWS, 2023, 42 (04) : 1300 - 1331
  • [49] Hydrogen/Deuterium Exchange Mass Spectrometry: Fundamentals, Limitations, and Opportunities
    Konermann, Lars
    Scrosati, Pablo M.
    MOLECULAR & CELLULAR PROTEOMICS, 2024, 23 (11)
  • [50] COMPUTATIONAL METHODS AND CHALLENGES IN HYDROGEN/DEUTERIUM EXCHANGE MASS SPECTROMETRY
    Claesen, Juergen
    Burzykowski, Tomasz
    MASS SPECTROMETRY REVIEWS, 2017, 36 (05) : 649 - 667
12345