Synthesis of indoles through acceptorless dehydrogenative coupling catalyzed by nickel on silica-alumina

被引：3

作者：

Charvieux, Aubin ^{[1
]}

Hammoud, Abdul Aziz ^{[1
]}

Duclos, Marie-Christine ^{[1
]}

Duguet, Nicolas ^{[1
]}

Metay, Estelle ^{[1
]}

机构：

[1] Univ Lyon, Univ Claude Bernard Lyon 1, CNRS,Inst Chim & Biochim Mol & Supramol, UMR 5246,INSA Lyon,CPE Lyon,ICBMS,Equipe Catalyse, Campus Lyon Tech Doua,Batiment Lederer, F-69100 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2021年 / 78卷

关键词：

Indole; Acceptorless dehydrogenative coupling; Heterogeneous nickel; Anilines; Diols; RUTHENIUM COMPLEX; N-HETEROCYCLIZATION; HYDRODEFLUORINATION; ALKYLATION; ANILINES; ALCOHOLS; DERIVATIVES; AMINOARENES; KETONES;

D O I：

10.1016/j.tetlet.2021.153270

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The high atom-economical formation of indoles from anilines and diols was described with affordable and easy to handle Ni/SiO2-Al2O3. After optimization, 2,3-dimethylindole was isolated with an excellent 98% yield in neat conditions. The scope of the reaction was studied and 13 indoles were isolated in 16-80% yields. (C) 2021 Elsevier Ltd. All rights reserved.

引用

页数：4

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