SARS-CoV-2 and pancreas: a potential interaction?

被引：22

作者：

Geravandi, Shirin ^{[1
]}

Mahmoudi-aznaveh, Azam ^{[2
]}

Azizi, Zahra ^{[2
]}

Maedler, Kathrin ^{[1
]}

Ardestani, Amin ^{[1
,2
]}

机构：

[1] Univ Bremen, Ctr Biomol Interact Bremen, Bremen, Germany

[2] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Mol Med, Tehran, Iran

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2021年 / 32卷 / 11期

关键词：

INFECTION;

D O I：

10.1016/j.tem.2021.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19-diabetes fatal bidirectional relationship.

引用

页码：842 / 845

页数：4

共 15 条

[1] SARS-CoV-2 Cell Entry Factors ACE2 and TMPRSS2 Are Expressed in the Microvasculature and Ducts of Human Pancreas but Are Not Enriched in β Cells [J].

Coate, Katie C. ;

Cha, Jeeyeon ;

Shrestha, Shristi ;

Wang, Wenliang ;

Goncalves, Luciana Mateus ;

Almaca, Joana ;

Kapp, Meghan E. ;

Fasolino, Maria ;

Morgan, Ashleigh ;

Dai, Chunhua ;

Saunders, Diane C. ;

Bottino, Rita ;

Aramandla, Radhika ;

Jenkins, Regina ;

Stein, Roland ;

Kaestner, Klaus H. ;

Vahedi, Golnaz ;

Brissova, Marcela ;

Powers, Alvin C. .

CELL METABOLISM, 2020, 32 (06) :1028-1040.e4

[2] SARS-CoV-2 Receptor Angiotensin I-Converting Enzyme Type 2 (ACE2) Is Expressed in Human Pancreatic β-Cells and in the Human Pancreas Microvasculature [J].

Fignani, Daniela ;

Licata, Giada ;

Brusco, Noemi ;

Nigi, Laura ;

Grieco, Giuseppina E. ;

Marselli, Lorella ;

Overbergh, Lut ;

Gysemans, Conny ;

Colli, Maikel L. ;

Marchetti, Piero ;

Mathieu, Chantal ;

Eizirik, Decio L. ;

Sebastiani, Guido ;

Dotta, Francesco .

FRONTIERS IN ENDOCRINOLOGY, 2020, 11

[3] Enteroviruses and T1D: Is It the Virus, the Genes or Both which Cause T1D [J].

Geravandi, Shirin ;

Liu, Huan ;

Maedler, Kathrin .

MICROORGANISMS, 2020, 8 (07) :1-20

[4] The protein expression profile of ACE2 in human tissues [J].

Hikmet, Feria ;

Mear, Loren ;

Edvinsson, Asa ;

Micke, Patrick ;

Uhlen, Mathias ;

Lindskog, Cecilia .

MOLECULAR SYSTEMS BIOLOGY, 2020, 16 (07)

[5] Expression of SARS-CoV-2 Entry Factors in the Pancreas of Normal Organ Donors and Individuals with COVID-19 [J].

Kusmartseva, Irina ;

Wu, Wenting ;

Syed, Farooq ;

Van Der Heide, Verena ;

Jorgensen, Marda ;

Joseph, Paul ;

Tang, Xiaohan ;

Candelario-Jalil, Eduardo ;

Yang, Changjun ;

Nick, Harry ;

Harbert, Jack L. ;

Posgai, Amanda L. ;

Paulsen, John David ;

Lloyd, Richard ;

Cechin, Sirlene ;

Pugliese, Alberto ;

Campbell-Thompson, Martha ;

Vander Heide, Richard S. ;

Evans-Molina, Carmella ;

Homann, Dirk ;

Atkinson, Mark A. .

CELL METABOLISM, 2020, 32 (06) :1041-1051.e6

[6] ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection [J].

Liu, Furong ;

Long, Xin ;

Zhang, Bixiang ;

Zhang, Wanguang ;

Chen, Xiaoping ;

Zhang, Zhanguo .

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2020, 18 (09) :2128-+

[7] Acute and long-term disruption of glycometabolic control after SARS-CoV-2 infection [J].

Montefusco, Laura ;

Ben Nasr, Moufida ;

D'Addio, Francesca ;

Loretelli, Cristian ;

Rossi, Antonio ;

Pastore, Ida ;

Daniele, Giuseppe ;

Abdelsalam, Ahmed ;

Maestroni, Anna ;

Dell'Acqua, Marco ;

Ippolito, Elio ;

Assi, Emma ;

Usuelli, Vera ;

Seelam, Andy Joe ;

Fiorina, Roberta Maria ;

Chebat, Enrica ;

Morpurgo, Paola ;

Lunati, Maria Elena ;

Bolla, Andrea Mario ;

Finzi, Giovanna ;

Abdi, Reza ;

Bonventre, Joseph V. ;

Rusconi, Stefano ;

Riva, Agostino ;

Corradi, Domenico ;

Santus, Pierachille ;

Nebuloni, Manuela ;

Folli, Franco ;

Zuccotti, Gian Vincenzo ;

Galli, Massimo ;

Fiorina, Paolo .

NATURE METABOLISM, 2021, 3 (06) :774-+

[8] SARS-CoV-2 infects and replicates in cells of the human endocrine and exocrine pancreas [J].

Mueller, Janis A. ;

Gross, Ruediger ;

Conzelmann, Carina ;

Krueger, Jana ;

Merle, Uta ;

Steinhart, Johannes ;

Weil, Tatjana ;

Koepke, Lennart ;

Bozzo, Caterina Prelli ;

Read, Clarissa ;

Fois, Giorgio ;

Eiseler, Tim ;

Gehrmann, Julia ;

van Vuuren, Joanne ;

Wessbecher, Isabel M. ;

Frick, Manfred ;

Costa, Ivan G. ;

Breunig, Markus ;

Gruener, Beate ;

Peters, Lynn ;

Schuster, Michael ;

Liebau, Stefan ;

Seufferlein, Thomas ;

Stenger, Steffen ;

Stenzinger, Albrecht ;

MacDonald, Patrick E. ;

Kirchhoff, Frank ;

Sparrer, Konstantin M. J. ;

Walther, Paul ;

Lickert, Heiko ;

Barth, Thomas F. E. ;

Wagner, Martin ;

Muench, Jan ;

Heller, Sandra ;

Kleger, Alexander .

NATURE METABOLISM, 2021, 3 (02) :149-+

[9] Deleterious Effects of SARS-CoV-2 Infection on Human Pancreatic Cells [J].

Shaharuddin, Syairah Hanan ;

Wang, Victoria ;

Santos, Roberta S. ;

Gross, Andrew ;

Wang, Yizhou ;

Jawanda, Harneet ;

Zhang, Yi ;

Hasan, Wohaib ;

Garcia, Gustavo, Jr. ;

Arumugaswami, Vaithilingaraja ;

Sareen, Dhruv .

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2021, 11

[10] Viral infiltration of pancreatic islets in patients with COVID-19 [J].

Steenblock, Charlotte ;

Richter, Stefanie ;

Berger, Ilona ;

Barovic, Marko ;

Schmid, Janine ;

Schubert, Undine ;

Jarzebska, Natalia ;

von Maessenhausen, Anne ;

Linkermann, Andreas ;

Schuermann, Annette ;

Pablik, Jessica ;

Dienemann, Thomas ;

Evert, Katja ;

Rodionov, Roman N. ;

Semenova, Natalia Y. ;

Zinserling, Vsevolod A. ;

Gainetdinov, Raul R. ;

Baretton, Gustavo ;

Lindemann, Dirk ;

Solimena, Michele ;

Ludwig, Barbara ;

Bornstein, Stefan R. .

NATURE COMMUNICATIONS, 2021, 12 (01)

← 1 2 →