Monoclonal Antibody Therapy in a Vaccine Breakthrough SARS-CoV-2 Hospitalized Delta (B.1.617.2) Variant Case

被引：19
|
作者：
Connor, Bradley A. [1 ,2 ,3 ]
Couto-Rodriguez, Mara [4 ]
Barrows, Joseph E. [4 ]
Gardner, Morgan [2 ,3 ]
Rogova, Marina [2 ,3 ]
O'Hara, Niamh B. [4 ,5 ]
Nagy-Szakal, Dorottya [4 ,5 ]
机构：
[1] Weill Cornell Med, New York, NY 10021 USA
[2] New York Ctr Travel & Trop Med, New York, NY 10022 USA
[3] GeoSentinel, New York, NY 12201 USA
[4] Biotia Inc, New York, NY USA
[5] SUNY Downstate Hlth Sci Univ, Dept Cell Biol, Coll Med, New York, NY USA
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2021年 / 110卷
关键词：
B; 1; 617; 2; Delta variant; SARS-CoV-2; COVID-19; variant of concern; breakthrough; monoclonal antibody therapy; bamlanivimab; etesevimab;
D O I：
10.1016/j.ijid.2021.07.029
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
We present two Delta (B.1.617.2) vaccine breakthrough individuals, a father and son living in separate households. The older, 63-year-old patient's symptoms were severe enough to require hospitalization. De-spite having a high titer of anti-spike IgG in his serum, his symptoms resolved within 24 hours following monoclonal antibody (bamlanivimab/etesevimab) therapy. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )
引用
收藏
页码：232 / 234
页数：3
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