Monoclonal Antibody Therapy in a Vaccine Breakthrough SARS-CoV-2 Hospitalized Delta (B.1.617.2) Variant Case

被引：19

作者：

Connor, Bradley A. ^{[1
,2
,3
]}

Couto-Rodriguez, Mara ^{[4
]}

Barrows, Joseph E. ^{[4
]}

Gardner, Morgan ^{[2
,3
]}

Rogova, Marina ^{[2
,3
]}

O'Hara, Niamh B. ^{[4
,5
]}

Nagy-Szakal, Dorottya ^{[4
,5
]}

机构：

[1] Weill Cornell Med, New York, NY 10021 USA

[2] New York Ctr Travel & Trop Med, New York, NY 10022 USA

[3] GeoSentinel, New York, NY 12201 USA

[4] Biotia Inc, New York, NY USA

[5] SUNY Downstate Hlth Sci Univ, Dept Cell Biol, Coll Med, New York, NY USA

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2021年 / 110卷

关键词：

B; 1; 617; 2; Delta variant; SARS-CoV-2; COVID-19; variant of concern; breakthrough; monoclonal antibody therapy; bamlanivimab; etesevimab;

D O I：

10.1016/j.ijid.2021.07.029

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We present two Delta (B.1.617.2) vaccine breakthrough individuals, a father and son living in separate households. The older, 63-year-old patient's symptoms were severe enough to require hospitalization. De-spite having a high titer of anti-spike IgG in his serum, his symptoms resolved within 24 hours following monoclonal antibody (bamlanivimab/etesevimab) therapy. (c) 2021 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

引用

页码：232 / 234

页数：3

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