Efficient gene delivery with paclitaxel-loaded DNA-hybrid polyplexes based on cationic polyhedral oligomeric silsesquioxanes

被引：78

作者：

Loh, Xian Jun ^{[1
]}

Zhang, Zhong-Xing ^{[1
]}

Mya, Khine Yi ^{[1
]}

Wu, Yun-long ^{[2
]}

He, Chao Bin ^{[1
]}

Li, Jun ^{[1
,2
]}

机构：

[1] ASTAR, IMRE, Singapore 117602, Singapore

[2] NUS, Div Bioengn, Fac Engn, Singapore 117574, Singapore

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2010年 / 20卷 / 47期

关键词：

BIODEGRADABLE COPOLYMER; TRANSGENE EXPRESSION; CO-DELIVERY; VECTORS; POLYETHYLENEIMINE; NANOCOMPOSITES; TRANSFECTION; MICELLES; POLYMERS; CELLS;

D O I：

10.1039/c0jm01461c

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We present a novel hybrid cationic polymer based on polyhedral oligomeric silsesquioxanes (POSS). This is the first report of using a cationic POSS-based material for gene delivery. Due to its amphiphilic properties, hydrophobic drugs such as paclitaxel can be encapsulated within the hydrophobic core of this polymer. In this paper, it is shown that paclitaxel-encapsulated hybrid POSS-based polyplexes show superior gene transfection efficiency in human breast cancer cells than the non drug-loaded polyplexes.

引用

收藏

页码：10634 / 10642

页数：9

相关论文

共 40 条

[1] CRITICAL MICELLIZATION PHENOMENA IN BLOCK POLYELECTROLYTE SOLUTIONS [J].

ASTAFIEVA, I ;

ZHONG, XF ;

EISENBERG, A .

MACROMOLECULES, 1993, 26 (26) :7339-7352

[2] Effect of size and serum proteins on transfection efficiency of poly((2-dimethylamino)ethyl methacrylate)-plasmid nanoparticles [J].

Cherng, JY ;

vandeWetering, P ;

Talsma, H ;

Crommelin, DJA ;

Hennink, WE .

PHARMACEUTICAL RESEARCH, 1996, 13 (07) :1038-1042

[3] Microtubular disruption prolongs the expression of human bilirubin-uridinediphosphoglucuronate-glucuronosyltransferase-1 gene transferred into Gunn rat livers [J].

Chowdhury, NR ;

Hays, RM ;

Bommineni, VR ;

Franki, N ;

Chowdhury, JR ;

Wu, CH ;

Wu, GY .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (04) :2341-2346

[4] Development of a novel endosomolytic diblock copolymer for siRNA delivery [J].

Convertine, Anthony J. ;

Benoit, Danielle S. W. ;

Duvall, Craig L. ;

Hoffman, Allan S. ;

Stayton, Patrick S. .

JOURNAL OF CONTROLLED RELEASE, 2009, 133 (03) :221-229

[5] Cationic polymer based gene delivery systems [J].

De Smedt, SC ;

Demeester, J ;

Hennink, WE .

PHARMACEUTICAL RESEARCH, 2000, 17 (02) :113-126

[6] Combinatorial modification of degradable polymers enables transfection of human cells comparable to adenovirus [J].

Green, Jordan J. ;

Zugates, Gregory T. ;

Tedford, Nathan C. ;

Huang, Yu-Hung ;

Griffith, Linda G. ;

Lauffenburger, Douglas A. ;

Sawicki, Janet A. ;

Langer, Robert ;

Anderson, Daniel G. .

ADVANCED MATERIALS, 2007, 19 (19) :2836-+

[7] Permeabilizing action of polyethyleneimine on Salmonella typhimurium involves disruption of the outer membrane and interactions with lipopolysaccharide [J].

Helander, IM ;

Latva-Kala, K ;

Lounatmaa, K .

MICROBIOLOGY-UK, 1998, 144 :385-390

[8] Polyethyleneimine is an effective permeabilizer of Gram-negative bacteria [J].

Helander, IM ;

Alakomi, HL ;

LatvaKala, K ;

Koski, P .

MICROBIOLOGY-UK, 1997, 143 :3193-3199

[9] Silica nanoparticles as a delivery system for nucleic acid-based reagents [J].

Hom, Christopher ;

Lu, Jie ;

Tamanoi, Fuyuhiko .

JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (35) :6308-6316

[10] Heparin-modified PEI encapsulated in thermosensitive hydrogels for efficient gene delivery and expression [J].

Hu, Chao-Hua ;

Zhang, Lei ;

Wu, De-Qun ;

Cheng, Si-Xue ;

Zhang, Xian-Zheng ;

Zhuo, Ren-Xi .

JOURNAL OF MATERIALS CHEMISTRY, 2009, 19 (20) :3189-3197

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