Rapid Evolution of H7N9 Highly Pathogenic Viruses that Emerged in China in 2017

被引：280

作者：

Shi, Jianzhong ^{[1
]}

Deng, Guohua ^{[1
]}

Ma, Shujie ^{[1
]}

Zeng, Xianying ^{[1
]}

Yin, Xin ^{[1
]}

Li, Mei ^{[1
]}

Zhang, Bo ^{[1
]}

Cui, Pengfei ^{[1
]}

Chen, Yan ^{[1
]}

Yang, Huanliang ^{[1
]}

Wan, Xiaopeng ^{[1
]}

Liu, Liling ^{[1
]}

Chen, Pucheng ^{[1
]}

Jiang, Yongping ^{[1
]}

Guan, Yuntao ^{[1
]}

Liu, Jinxiong ^{[1
]}

Gu, Wenli ^{[1
]}

Han, Shuyu ^{[1
]}

Song, Yangming ^{[1
]}

Liang, Libin ^{[1
]}

Qu, Zhiyuan ^{[1
]}

Hou, Yujie ^{[1
]}

Wang, Xiurong ^{[1
]}

Bao, Hongmei ^{[1
]}

Tian, Guobin ^{[1
]}

Li, Yanbing ^{[1
]}

Jiang, Li ^{[1
]}

Li, Chengjun ^{[1
]}

Chen, Hualan ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Harbin 150069, Heilongjiang, Peoples R China

来源：

CELL HOST & MICROBE | 2018年 / 24卷 / 04期

基金：

中国国家自然科学基金;

关键词：

H5N1 AVIAN INFLUENZA; SINGLE-AMINO-ACID; A VIRUS; GENE CONTRIBUTES; MOLECULAR-BASIS; HIGH VIRULENCE; MOUSE MODEL; POULTRY; REPLICATION; POLYMERASE;

D O I：

10.1016/j.chom.2018.08.006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

H7N9 low pathogenic influenza viruses emerged in China in 2013 and mutated to highly pathogenic strains in 2017, resulting in human infections and disease in chickens. To control spread, a bivalent H5/H7 inactivated vaccine was introduced in poultry in September 2017. To monitor virus evolution and vaccine efficacy, we collected 53,884 poultry samples across China from February 2017 to January 2018. We isolated 252 H7N9 low pathogenic viruses, 69 H7N9 highly pathogenic viruses, and one H7N2 highly pathogenic virus, of which two low pathogenic and 14 highly pathogenic strains were collected after vaccine introduction. Genetic analysis of highly pathogenic strains revealed nine genotypes, one of which is predominant and widespread and contains strains exhibiting high virulence in mice. Additionally, some H7N9 and H7N2 viruses carrying duck virus genes are lethal in ducks. Thus, although vaccination reduced H7N9 infections, the increased virulence and expanded host range to ducks pose new challenges.

引用

页码：558 / +

页数：18

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