Current concepts - A critical appraisal of "chronic Lyme disease''

被引：317
作者：
Feder, Henry M., Jr. [1 ]
Johnson, Barbara J. B.
O'Connell, Susan
Shapiro, Eugene D.
Steere, Allen C.
Wormser, Gary P.
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Family Med, Farmington, CT 06030 USA
[2] Connecticut Childrens Med Ctr, Dept Family Med, Hartford, CT USA
[3] Connecticut Childrens Med Ctr, Dept Pediat, Hartford, CT USA
[4] Ctr Dis Control & Prevent, Div Vector Borne Infect Dis, Microbiol Lab, Ft Collins, CO USA
[5] Southampton Gen Hosp, Hlth Protect Agcy Microbiol Lab, Lyme Borreliosis Unit, Southampton SO9 4XY, Hants, England
[6] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06510 USA
[7] Yale Univ, Sch Med, Dept Epidemiol & Publ Hlth, New Haven, CT 06510 USA
[8] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Rheumatol Allergy & Immunol, Boston, MA USA
[9] New York Med Coll, Dept Med, Div Infect Dis, Valhalla, NY 10595 USA
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2007年 / 357卷 / 14期
关键词：
D O I：
10.1056/NEJMra072023
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
"Chronic Lyme disease" is often used to explain persistent pain, fatigue, and neurocognitive symptoms in patients without any evidence of previous acute Lyme disease. Once this diagnosis is given, prolonged treatment with multiple antimicrobial agents may follow. This review examines the scientific evidence for chronic borrelia infection and explains the approach to clinical evaluation and management in patients with a diagnosis of chronic Lyme disease. Copyright © 2007 Massachusetts Medical Society.
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收藏
页码：1422 / 1430
页数：9
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