Expression of STIM1 is associated with tumor aggressiveness and poor prognosis in breast cancer

被引：23
|
作者：
Yang, Yanfang [1 ]
Jiang, Zhansheng [2 ]
Wang, Bin [1 ]
Chang, Lili [1 ]
Liu, Jun [1 ]
Zhang, Lina [1 ]
Gu, Lin [1 ]
机构：
[1] Tianjin Med Univ, Canc Inst & Hosp, Dept Breast Canc 2, Tianjin, Peoples R China
[2] Tianjin Med Univ, Canc Inst & Hosp, Dept Integrat Oncol, Tianjin, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2017年 / 213卷 / 09期
关键词：
Breast cancer; Prognosis; Survival; STIM1; CELL-PROLIFERATION; PROSTATE-CANCER; CALCIUM-ENTRY; CRAC CHANNELS; CA2+ INFLUX; STORE; MICRORNA-185; SUPPRESSION; METASTASIS; STATISTICS;
D O I：
10.1016/j.prp.2017.08.006
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
STIM1 has been confirmed a key role involving in breast cancer proliferation and metastasis in vitro studies and its value in breast cancer patients is still to be defined. In this study, we investigate the correlation between STIM1 expressions with clinicopathologic features and prognosis quantified by disease-free survival (DFS) and overall survival (OS). To assess STIM1 expression, we conducted immunohistochemistry assays using breast cancer tissues encompassing a total of 165 breast cancer cases with detailed follow-up data and 40 cases of matched samples including cancer and adjacent normal tissues. STIM1 expression was present in 66.1% (109/165) of breast cancer cases which was significantly higher than adjacent non-tumor tissues. Larger tumors, lymphnode metastasis and negative estrogen receptor were positively associated with STIM1 overexpression. Furthermore, STIM1 expression was significantly associated with worse DFS (P = 0.03) rather than OS in breast cancer patients.
引用
收藏
页码：1043 / 1047
页数：5
相关论文
共 50 条
  • [1] STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer
    Zhang, Z.
    Liu, X.
    Feng, B.
    Liu, N.
    Wu, Q.
    Han, Y.
    Nie, Y.
    Wu, K.
    Shi, Y.
    Fan, D.
    ONCOGENE, 2015, 34 (37) : 4808 - 4820
  • [2] STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer
    Z Zhang
    X Liu
    B Feng
    N Liu
    Q Wu
    Y Han
    Y Nie
    K Wu
    Y Shi
    D Fan
    Oncogene, 2015, 34 : 4808 - 4820
  • [3] Erratum: STIM1, a direct target of microRNA-185, promotes tumor metastasis and is associated with poor prognosis in colorectal cancer
    Z Zhang
    X Liu
    B Feng
    N Liu
    Q Wu
    Y Han
    Y Nie
    K Wu
    Y Shi
    D Fan
    Oncogene, 2016, 35 : 6043 - 6043
  • [4] STIM1 expression and single nucleotide polymorphisms (SNPs) are associated with breast cancer clinical outcome
    Hsu, Yuwen
    Yang, Yuchen
    Chang, Weichiao
    CANCER SCIENCE, 2018, 109 : 655 - 655
  • [5] Overexpression of MSK1 is associated with tumor aggressiveness and poor prognosis in colorectal cancer
    Fu, Xinhui
    Fan, Xinjuan
    Hu, Jun
    Zou, Hongzhi
    Chen, Zhiting
    Liu, Qi
    Ni, Beibei
    Tan, Xiaoli
    Su, Qiao
    Wang, Jingxuan
    Wang, Lei
    Wang, Jianping
    DIGESTIVE AND LIVER DISEASE, 2017, 49 (06) : 683 - 691
  • [6] miRNA-dependent regulation of STIM1 expression in breast cancer
    Rashmi P. Kulkarni
    Asha Elmi
    Ethel Alcantara-Adap
    Satanay Hubrack
    Nancy Nader
    Fang Yu
    Maya Dib
    Vimal Ramachandran
    Hani Najafi Shoushtari
    Khaled Machaca
    Scientific Reports, 9
  • [7] miRNA-dependent regulation of STIM1 expression in breast cancer
    Kulkarni, Rashmi P.
    Elmi, Asha
    Alcantara-Adap, Ethel
    Hubrack, Satanay
    Nader, Nancy
    Yu, Fang
    Dib, Maya
    Ramachandran, Vimal
    Shoushtari, Hani Najafi
    Machaca, Khaled
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [8] Low CA II expression is associated with tumor aggressiveness and poor prognosis in gastric cancer patients
    Hu, Xiaotong
    Huang, Zhongting
    Liao, Zhongcai
    He, Chao
    Fang, Xiao
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2014, 7 (10): : 6716 - 6724
  • [9] Squalene epoxidase expression is associated with breast tumor progression and with a poor prognosis in breast cancer
    Kim, Nah Him
    Park, Min Ho
    Kweon, Sun-Seog
    Cii, Namki
    Lee, Ji Shin
    ONCOLOGY LETTERS, 2021, 21 (04)
  • [10] Increased expression of Golgi phosphoprotein-3 is associated with tumor aggressiveness and poor prognosis of prostate cancer
    Hua, Xing
    Yu, Lina
    Pan, Wenhai
    Huang, Xiaoxiao
    Liao, Zexiao
    Xian, Qi
    Fang, Li
    Shen, Hong
    DIAGNOSTIC PATHOLOGY, 2012, 7
12345