Synthesis of substituted 8-aminoquinolines and phenanthrolines through a Povarov approach

被引：27

作者：

De, Kavita ^{[1
]}

Legros, Julien ^{[1
]}

Crousse, Benoit ^{[1
]}

Chandrasekaran, Srinivasan ^{[2
]}

Bonnet-Delpona, Daniele ^{[1
]}

机构：

[1] Univ Paris Sud, Lab BioCIS CNRS, Fac Pharm, F-92296 Chatenay Malabry, France

[2] Indian Inst Sci, Dept Organ Chem, Bangalore 560012, Karnataka, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 02期

关键词：

FLUORINATED ALCOHOLS; OLEFIN EPOXIDATION; DOMINO REACTION; HEXAFLUOROISOPROPANOL; 1,10-PHENANTHROLINE; DERIVATIVES; CATALYSIS; SOLVENTS; LACTAMS; DNA;

D O I：

10.1039/c0ob00496k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 8-aminoquinolines and 1,10-phenanthrolines with substituents in alpha of the nitrogen has been performed through an inverse-demanding aza-Diels-Alder (Povarov reaction) in the fluoroalcohols TFE or HFIP. This path involves simple starting materials: 1,2-phenylenediamines, enol ethers and aldehydes.

引用

页码：347 / 350

页数：4

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