Latrogenic botulism due to therapeutic botulinum toxin A injection in a pediatric patient

被引：39

作者：

Crowner, Beth E.

Brunstrom, Janice E.

Racette, Brad A.

机构：

[1] Washington Univ, Sch Med, Amer Parkinson Dis Assoc Adv Ctr Parkinson Res, Dept Neurol, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Program Phys Therapy, St Louis, MO 63130 USA

[3] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63130 USA

来源：

CLINICAL NEUROPHARMACOLOGY | 2007年 / 30卷 / 05期

关键词：

cerebral palsy; botulinum toxin A; botulism;

D O I：

10.1097/WNF.0B013E31804B1A0D

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Botulinum toxin A is commonly used to reduce spasticity and dystonia in children with cerebral palsy. We report a pediatric patient who developed systemic botulism as a result of a severe overdose of the injected toxin (40 U/kg). This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children.

引用

页码：310 / 313

页数：4

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