Redox Regulation of Lipid Mobilization in Adipose Tissues

被引：37

作者：

Abou-Rjeileh, Ursula ^{[1
]}

Contreras, G. Andres ^{[1
]}

机构：

[1] Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, E Lansing, MI 48824 USA

来源：

ANTIOXIDANTS | 2021年 / 10卷 / 07期

基金：

美国食品与农业研究所;

关键词：

lipolysis; lipogenesis; redox signaling; antioxidants; oxidative stress; DEPENDENT PROTEIN-KINASE; GLUTATHIONE-PEROXIDASE; 3; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; ADENYLYL-CYCLASE; GROWTH-HORMONE; NATRIURETIC-PEPTIDES; ANTIOXIDANT DEFENSE;

D O I：

10.3390/antiox10071090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a paramount process in regulating systemic energy metabolism. Reactive oxygen and nitrogen species (ROS and RNS) are byproducts of cellular metabolism that exert signaling functions in several cellular processes, including lipolysis and lipogenesis. During lipolysis, the adipose tissue generates ROS and RNS and thus requires a robust antioxidant response to maintain tight regulation of redox signaling. This review will discuss the production of ROS and RNS within the adipose tissue, their role in regulating lipolysis and lipogenesis, and the implications of antioxidants on lipid mobilization.

引用

页数：18

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