Redox Regulation of Lipid Mobilization in Adipose Tissues

被引：37
作者：
Abou-Rjeileh, Ursula [1 ]
Contreras, G. Andres [1 ]
机构：
[1] Michigan State Univ, Coll Vet Med, Dept Large Anim Clin Sci, E Lansing, MI 48824 USA
来源：
ANTIOXIDANTS | 2021年 / 10卷 / 07期
基金：
美国食品与农业研究所;
关键词：
lipolysis; lipogenesis; redox signaling; antioxidants; oxidative stress; DEPENDENT PROTEIN-KINASE; GLUTATHIONE-PEROXIDASE; 3; NITRIC-OXIDE SYNTHASE; OXIDATIVE STRESS; INSULIN-RESISTANCE; HYDROGEN-PEROXIDE; ADENYLYL-CYCLASE; GROWTH-HORMONE; NATRIURETIC-PEPTIDES; ANTIOXIDANT DEFENSE;
D O I：
10.3390/antiox10071090
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lipid mobilization in adipose tissues, which includes lipogenesis and lipolysis, is a paramount process in regulating systemic energy metabolism. Reactive oxygen and nitrogen species (ROS and RNS) are byproducts of cellular metabolism that exert signaling functions in several cellular processes, including lipolysis and lipogenesis. During lipolysis, the adipose tissue generates ROS and RNS and thus requires a robust antioxidant response to maintain tight regulation of redox signaling. This review will discuss the production of ROS and RNS within the adipose tissue, their role in regulating lipolysis and lipogenesis, and the implications of antioxidants on lipid mobilization.
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页数：18
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共 125 条
[91]   Reactive oxygen species in phagocytic leukocytes [J].
Robinson, John M. .
HISTOCHEMISTRY AND CELL BIOLOGY, 2008, 130 (02) :281-297
[92]   Oxidative stress and protein carbonylation in adipose tissue - Implications for insulin resistance and diabetes mellitus [J].
Ruskovska, Tatjana ;
Bernlohr, David A. .
JOURNAL OF PROTEOMICS, 2013, 92 :323-334
[93]   CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization [J].
Sahu-Osen, Anita ;
Montero-Moran, Gabriela ;
Schittmayer, Matthias ;
Fritz, Katarina ;
Dinh, Anna ;
Chang, Yu-Fang ;
McMahon, Derek ;
Boeszoermenyi, Andras ;
Cornaciu, Irina ;
Russell, Deanna ;
Oberer, Monika ;
Carman, George M. ;
Birner-Gruenberger, Ruth ;
Brasaemle, Dawn L. .
JOURNAL OF LIPID RESEARCH, 2015, 56 (01) :109-121
[94]   Role of growth hormone in regulating lipolysis, proteolysis, and hepatic glucose production during fasting [J].
Sakharova, Alla A. ;
Horowitz, Jeffrey F. ;
Surya, Sowmya ;
Goldenberg, Naila ;
Harber, Matthew P. ;
Symons, Kathy ;
Barkan, Ariel .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (07) :2755-2759
[95]   Transcriptomic profiling of adipose tissue inflammation, remodeling, and lipid metabolism in periparturient dairy cows (Bos taurus) [J].
Salcedo-Tacuma, David ;
Parales-Giron, Jair ;
Prom, Crystal ;
Chirivi, Miguel ;
Laguna, Juliana ;
Lock, Adam L. ;
Contreras, G. Andres .
BMC GENOMICS, 2020, 21 (01)
[96]   Involvement of a cGMP-dependent pathway in the natriuretic peptide-mediated hormone-sensitive lipase phosphorylation in human adipocytes [J].
Sengenès, C ;
Bouloumié, A ;
Hauner, H ;
Berlan, M ;
Busse, R ;
Lafontan, M ;
Galitzky, J .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (49) :48617-48626
[97]   Natriuretic peptides:: a new lipolytic pathway in human adipocytes [J].
Sengenès, C ;
Berlan, M ;
De Glisezinski, I ;
Lafontan, M ;
Galitzky, J .
FASEB JOURNAL, 2000, 14 (10) :1345-1351
[98]   Differences in type II, IV, V and VI adenylyl cyclase isoform expression between rat preadipocytes and adipocytes [J].
Serazin-Leroy, V ;
Morot, M ;
de Mazancourt, P ;
Giudicelli, Y .
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, 2001, 1550 (01) :37-51
[99]   Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance [J].
Shankar, RR ;
Wu, YG ;
Shen, HQ ;
Zhu, JS ;
Baron, AD .
DIABETES, 2000, 49 (05) :684-687
[100]   Mechanisms of disease - Glucose transporters and insulin action - Implications for insulin resistance and diabetes mellitus [J].
Shepherd, PR ;
Kahn, BB .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (04) :248-257
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