Nanomedicines in the Management of Alzheimer's Disease: Current View and Future Prospects

被引:23
作者
Chopra, Hitesh [1 ]
Bibi, Shabana [2 ,3 ]
Singh, Inderbir [1 ]
Kamal, Mohammad Amjad [4 ,5 ,6 ,7 ]
Islam, Fahadul [6 ]
Alhumaydhi, Fahad A. [8 ]
Emran, Talha Bin [6 ,9 ]
Cavalu, Simona [10 ]
机构
[1] Chitkara Univ, Chitkara Coll Pharm, Rajpura, Punjab, India
[2] Shifa Tameer Emillat Univ, Dept Biosci, Islamabad, Pakistan
[3] Yunnan Univ, Coll Ecol & Environm Sci, Yunnan Herbal Lab, Kunming, Peoples R China
[4] Sichuan Univ, West China Hosp, Inst Syst Genet, Frontiers Sci Ctr Dis Related Mol Network, Chengdu, Peoples R China
[5] King Abdulaziz Univ, King Fahd Med Res Ctr, Jeddah, Saudi Arabia
[6] Daffodil Int Univ, Fac Allied Hlth Sci, Dept Pharm, Dhaka, Bangladesh
[7] Novel Global Community Educ Fdn, Enzymo, Hebersham, NSW, Australia
[8] Qassim Univ, Coll Appl Med Sci, Dept Med Labs, Buraydah, Saudi Arabia
[9] BGC Trust Univ Bangladesh, Dept Pharm, Chittagong, Bangladesh
[10] Univ Oradea, Fac Med & Pharm, Oradea, Romania
来源
FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷
关键词
Alzheimer's disease; neurodegenerative disorders; nanotechnology; nanomedicine; dementia; aging; IRON-OXIDE NANOPARTICLES; AMYLOID-BETA AGGREGATION; LOADED CHITOSAN NANOPARTICLES; IN-VITRO; DECORATED NANOLIPOSOMES; GOLD NANOPARTICLES; QUANTUM DOTS; A-BETA-1-42; PEPTIDES; THERAPEUTIC APPROACH; BINDING-AFFINITY;
D O I
10.3389/fnagi.2022.879114
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Alzheimer's disease (AD) is a kind of dementia that creates serious challenges for sufferers' memory, thinking, and behavior. It commonly targeting the aging population and decay the brain cells, despite attempts have been performed to enhance AD diagnostic and therapeutic techniques. Hence, AD remains incurable owing to its complex and multifactorial consequences and still there is lack of appropriate diagnostics/therapeutics option for this severe brain disorder. Therefore, nanotechnology is currently bringing new tools and insights to improve the previous knowledge of AD and ultimately may provide a novel treatment option and a ray of hope to AD patients. Here in this review, we highlighted the nanotechnologies-based findings for AD, in both diagnostic and therapeutic aspects and explained how advances in the field of nanotechnology/nanomedicine could enhance patient prognosis and quality of life. It is highly expected these emerging technologies could bring a research-based revolution in the field of neurodegenerative disorders and may assist their clinical experiments and develop an efficacious drug for AD also. The main aim of review is to showcase readers the recent advances in nanotechnology-based approaches for treatment and diagnosing of AD.
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页数:17
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