Neuronal substrates of sleep homeostasis; lessons from flies, rats and mice

被引：34

作者：

Donlea, Jeffrey M. ^{[1
]}

Alam, Md Noor ^{[2
,3
]}

Szymusiak, Ronald ^{[1
,2
,3
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

[3] VA Greater Los Angeles Healthcare Syst, Res Serv, Los Angeles, CA 90073 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2017年 / 44卷

基金：

美国国家卫生研究院;

关键词：

ASTROCYTE-DERIVED ADENOSINE; EYE-MOVEMENT SLEEP; CHOLINERGIC NEURONS; HYPOCRETIN/OREXIN NEURONS; PREOPTIC HYPOTHALAMUS; GABAERGIC NEURONS; PROMOTING NEURONS; A(2A) RECEPTORS; A(1) RECEPTORS; REDUCED SLEEP;

D O I：

10.1016/j.conb.2017.05.003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sleep homeostasis is a fundamental property of vigilance state regulation that is highly conserved across species. Neuronal systems and circuits that underlie sleep homeostasis are not well understood. In Drosophila, a neuronal circuit involving neurons in the ellipsoid body and in the dorsal Fan-shaped body is a candidate for both tracing sleep need during waking and translating it to increased sleep drive and expression. Sleep homeostasis in rats and mice involves multiple neuromodulators acting on multiple wake- and sleep-promoting neuronal systems. A functional central homeostat emerges from A(1) receptor mediated actions of adenosine on wake-promoting neurons in the basal forebrain and hypothalamus, and A(2A) adenosine receptor-mediated actions on sleep-promoting neurons in the preoptic hypothalamus and nucleus accumbens.

引用

页码：228 / 235

页数：8

共 69 条

[1] Neuronal activity in the preoptic hypothalamus during sleep deprivation and recovery sleep [J].

Alam, Md. Aftab ;

Kumar, Sunil ;

McGinty, Dennis ;

Alam, Md. Noor ;

Szymusiak, Ronald .

JOURNAL OF NEUROPHYSIOLOGY, 2014, 111 (02) :287-299

[2] Basal forebrain control of wakefulness and cortical rhythms [J].

Anaclet, Christelle ;

Pedersen, Nigel P. ;

Ferrari, Loris L. ;

Venner, Anne ;

Bass, Caroline E. ;

Arrigoni, Elda ;

Fuller, Patrick M. .

NATURE COMMUNICATIONS, 2015, 6

[3] Adenosine and sleep-wake regulation [J].

Basheer, R ;

Strecker, RE ;

Thakkar, MM ;

McCarley, RW .

PROGRESS IN NEUROBIOLOGY, 2004, 73 (06) :379-396

[4] STIMULATION OF A(1) ADENOSINE RECEPTORS MIMICS THE ELECTROENCEPHALOGRAPHIC EFFECTS OF SLEEP-DEPRIVATION [J].

BENINGTON, JH ;

KODALI, SK ;

HELLER, HC .

BRAIN RESEARCH, 1995, 692 (1-2) :79-85

[5] RESTORATION OF BRAIN ENERGY-METABOLISM AS THE FUNCTION OF SLEEP [J].

BENINGTON, JH ;

HELLER, HC .

PROGRESS IN NEUROBIOLOGY, 1995, 45 (04) :347-360

[6] An Adenosine-Mediated Glial-Neuronal Circuit for Homeostatic Sleep [J].

Bjorness, Theresa E. ;

Dale, Nicholas ;

Mettlach, Gabriel ;

Sonneborn, Alex ;

Sahin, Bogachan ;

Fienberg, Allen A. ;

Yanagisawa, Masashi ;

Bibb, James A. ;

Greene, Robert W. .

JOURNAL OF NEUROSCIENCE, 2016, 36 (13) :3709-3721

[7] Control and Function of the Homeostatic Sleep Response by Adenosine A1 Receptors [J].

Bjorness, Theresa E. ;

Kelly, Christine L. ;

Gao, Tianshu ;

Poffenberger, Virginia ;

Greene, Robert W. .

JOURNAL OF NEUROSCIENCE, 2009, 29 (05) :1267-1276

[8]

Borbely A A, 1982, Hum Neurobiol, V1, P195

[9]

Borbely Alexander A, 2011, Handb Clin Neurol, V98, P205, DOI 10.1016/B978-0-444-52006-7.00013-7

[10] Drosophila hyperkinetic mutants have reduced sleep and impaired memory [J].

Bushey, Daniel ;

Huber, Reto ;

Tononi, Giulio ;

Cirelli, Chiara .

JOURNAL OF NEUROSCIENCE, 2007, 27 (20) :5384-5393

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