The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells?

被引：55

作者：

Callard, Robin E. ^{[1
]}

Harper, John I.

机构：

[1] UCL, Inst Child Hlth, Immunobiol Unit, London WC1N 1EH, England

[2] Great Ormond St Hosp Sick Children, Dept Dermatol, London WC1N 3JH, England

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 07期

关键词：

D O I：

10.1016/j.it.2007.05.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The skin barrier (stratum corneum) is a major factor for determining the nature of immune response to antigens presented at the skin surface. Genetic abnormalities in skin barrier function are associated with allergy and atopic dermatitis, and removal of the skin barrier by tape stripping results in dominant Th2 responses to protein antigens. Langerhans cells take up antigen applied to skin from which the skin barrier has been removed; they then migrate to draining lymph nodes and initiate typical Th2 responses. These observations lead us to propose that the high frequency of allergic disease in the industrialized world might be due to lifestyle choices that result in loss of integrity of the skin barrier such as excessive washing and exfoliation of the skin.

引用

页码：294 / 298

页数：5