The skin barrier, atopic dermatitis and allergy: a role for Langerhans cells?

被引：55
作者：
Callard, Robin E. [1 ]
Harper, John I.
机构：
[1] UCL, Inst Child Hlth, Immunobiol Unit, London WC1N 1EH, England
[2] Great Ormond St Hosp Sick Children, Dept Dermatol, London WC1N 3JH, England
来源：
TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 07期
关键词：
D O I：
10.1016/j.it.2007.05.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The skin barrier (stratum corneum) is a major factor for determining the nature of immune response to antigens presented at the skin surface. Genetic abnormalities in skin barrier function are associated with allergy and atopic dermatitis, and removal of the skin barrier by tape stripping results in dominant Th2 responses to protein antigens. Langerhans cells take up antigen applied to skin from which the skin barrier has been removed; they then migrate to draining lymph nodes and initiate typical Th2 responses. These observations lead us to propose that the high frequency of allergic disease in the industrialized world might be due to lifestyle choices that result in loss of integrity of the skin barrier such as excessive washing and exfoliation of the skin.
引用
收藏
页码：294 / 298
页数：5
相关论文
共 41 条
  • [1] Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells
    Allan, RS
    Smith, CM
    Belz, GT
    van Lint, AL
    Wakim, LM
    Heath, WR
    Carbone, FR
    [J]. SCIENCE, 2003, 301 (5641) : 1925 - 1928
  • [2] Role of Langerhans cells in cutaneous protective immunity: Is the reappraisal necessary?
    Asahina, Akihiko
    Tamaki, Kunihiko
    [J]. JOURNAL OF DERMATOLOGICAL SCIENCE, 2006, 44 (01) : 1 - 9
  • [3] The cornified envelope: A model of cell death in the skin
    Candi, E
    Schmidt, R
    Melino, G
    [J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (04) : 328 - 340
  • [4] Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7
    Caubet, C
    Jonca, N
    Brattsand, M
    Guerrin, M
    Bernard, D
    Schmidt, R
    Egelrud, T
    Simon, M
    Serre, G
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 122 (05) : 1235 - 1244
  • [5] Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
    Chavanas, S
    Bodemer, C
    Rochat, A
    Hamel-Teillac, D
    Ali, M
    Irvine, AD
    Bonafé, JL
    Wilkinson, J
    Taïeb, A
    Barrandon, Y
    Harper, JI
    de Prost, Y
    Hovnanian, A
    [J]. NATURE GENETICS, 2000, 25 (02) : 141 - 142
  • [6] The immunogenetics of asthma and eczema: A new focus on the epithelium
    Cookson, W
    [J]. NATURE REVIEWS IMMUNOLOGY, 2004, 4 (12) : 978 - 988
  • [7] Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci
    Cookson, WOCM
    Ubhi, B
    Lawrence, R
    Abecasis, GR
    Walley, AJ
    Cox, HE
    Coleman, R
    Leaves, NI
    Trembath, RC
    Moffatt, MF
    Harper, JI
    [J]. NATURE GENETICS, 2001, 27 (04) : 372 - 373
  • [8] New perspectives on epidermal barrier dysfunction in atopic dermatitis: Gene-environment interactions
    Cork, Michael J.
    Robinson, Darren A.
    Vasilopoulos, Yiannis
    Ferguson, Adam
    Moustafa, Manar
    MacGowan, Alice
    Duff, Gordon W.
    Ward, Simon J.
    Tazi-Ahnini, Rachid
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 118 (01) : 3 - 21
  • [9] The atopy patch test: An increased rate of reactivity in patients who have an air-exposed pattern of atopic eczema
    Darsow, U
    Vieluf, D
    Ring, J
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 1996, 135 (02) : 182 - 186
  • [10] Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
    Descargues, P
    Deraison, C
    Bonnart, C
    Kreft, M
    Kishibe, M
    Ishida-Yamamoto, A
    Elias, P
    Barrandon, Y
    Zambruno, G
    Sonnenberg, A
    Hovnanian, A
    [J]. NATURE GENETICS, 2005, 37 (01) : 56 - 65
12345