Cancer stem cells in breast and prostate: Fact or fiction?

被引：17

作者：

Sampayo, Rocio G. ^{[1
]}

Bissell, Mina J. ^{[2
]}

机构：

[1] Univ Calif Berkeley, Dept Chem & Biomol Engn, Berkeley, CA 94720 USA

[2] Lawrence Berkeley Natl Lab, Div Biol Syst & Engn, Berkeley, CA 94720 USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 144 | 2019年 / 144卷

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; HYPOXIA-INDUCIBLE FACTORS; TUMOR MICROENVIRONMENT; BONE-MARROW; PROSPECTIVE IDENTIFICATION; SOLID TUMORS; HIERARCHY; DORMANCY; MARKER; HETEROGENEITY;

D O I：

10.1016/bs.acr.2019.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Since the introduction of the cancer stem cell (CSC) hypothesis, accumulating evidence shows that most cancers present stem-like niches. However, therapies aimed at targeting this niche have not been as successful as expected. New evidence regarding CSCs hierarchy, similarities with normal tissue stem cells and cell plasticity might be key in understanding their role in cancer biology and how to efficiently eliminate them. In this Chapter, we discuss what is known in breast and prostate CSCs from their initial discoveries to the current therapeutic efforts in the field. Future challenges towards better CSC identification and isolation strategies will be key to shed light into how CSCs could accurately be targeted in combination to traditional therapies to ultimately pro-long patient survival.

引用

页码：315 / 341

页数：27

共 169 条

[41] Organoid Cultures Derived from Patients with Advanced Prostate Cancer [J].

Gao, Dong ;

Vela, Ian ;

Sboner, Andrea ;

Iaquinta, Phillip J. ;

Karthaus, Wouter R. ;

Gopalan, Anuradha ;

Dowling, Catherine ;

Wanjala, Jackline N. ;

Undvall, Eva A. ;

Arora, Vivek K. ;

Wongvipat, John ;

Kossai, Myriam ;

Ramazanoglu, Sinan ;

Barboza, Luendreo P. ;

Di, Wei ;

Cao, Zhen ;

Zhang, Qi Fan ;

Sirota, Inna ;

Ran, Leili ;

MacDonald, Theresa Y. ;

Beltran, Himisha ;

Mosquera, Juan-Miguel ;

Touijer, Karim A. ;

Scardino, Peter T. ;

Laudone, Vincent P. ;

Curtis, Kristen R. ;

Rathkopf, Dana E. ;

Morris, Michael J. ;

Danila, Daniel C. ;

Slovin, Susan F. ;

Solomon, Stephen B. ;

Eastham, James A. ;

Chi, Ping ;

Carver, Brett ;

Rubin, Mark A. ;

Scher, Howard I. ;

Clevers, Hans ;

Sawyers, Charles L. ;

Chen, Yu .

CELL, 2014, 159 (01) :176-187

[42] Cancer cell dormancy: mechanisms and implications of cancer recurrence and metastasis [J].

Gao, Xiao-lei ;

Zhang, Mei ;

Tang, Ya-ling ;

Liang, Xin-hua .

ONCOTARGETS AND THERAPY, 2017, 10 :5219-5228

[43] Epithelial plasticity and cancer stem cells: Major mechanisms of cancer pathogenesis and therapy resistance [J].

Garg, Minal .

WORLD JOURNAL OF STEM CELLS, 2017, 9 (08) :118-126

[44] ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome [J].

Ginestier, Christophe ;

Hur, Min Hee ;

Charafe-Jauffret, Emmanuelle ;

Monville, Florence ;

Dutcher, Julie ;

Brown, Marty ;

Jacquemier, Jocelyne ;

Viens, Patrice ;

Kleer, Celina G. ;

Liu, Suling ;

Schott, Anne ;

Hayes, Dan ;

Birnbaum, Daniel ;

Wicha, Max S. ;

Dontu, Gabriela .

CELL STEM CELL, 2007, 1 (05) :555-567

[45] CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts [J].

Ginestier, Christophe ;

Liu, Suling ;

Diebel, Mark E. ;

Korkaya, Hasan ;

Luo, Ming ;

Brown, Marty ;

Wicinski, Julien ;

Cabaud, Olivier ;

Charafe-Jauffret, Emmanuelle ;

Birnbaum, Daniel ;

Guan, Jun-Lin ;

Dontu, Gabriela ;

Wicha, Max S. .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (02) :485-497

[46] Does tumour dormancy offer a therapeutic target? [J].

Goss, Paul E. ;

Chambers, Ann F. .

NATURE REVIEWS CANCER, 2010, 10 (12) :871-877

[47] Prostate cancer cells with stem cell characteristics reconstitute the original human tumor in vivo [J].

Gu, Guangyu ;

Yuan, Jialing ;

Wils, Marcia ;

Kasper, Susan .

CANCER RESEARCH, 2007, 67 (10) :4807-4815

[48] Stochastic State Transitions Give Rise to Phenotypic Equilibrium in Populations of Cancer Cells [J].

Gupta, Piyush B. ;

Fillmore, Christine M. ;

Jiang, Guozhi ;

Shapira, Sagi D. ;

Tao, Kai ;

Kuperwasser, Charlotte ;

Lander, Eric S. .

CELL, 2011, 146 (04) :633-644

[49] Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening [J].

Gupta, Piyush B. ;

Onder, Tamer T. ;

Jiang, Guozhi ;

Tao, Kai ;

Kuperwasser, Charlotte ;

Weinberg, Robert A. ;

Lander, Eric S. .

CELL, 2009, 138 (04) :645-659

[50]

Hackel E., 1868, NATRULICHE SCHOPFUNG

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