Prevention of toxic effects of orally administered tartrazine by crocin in Wistar rats

被引：6

作者：

Altinoz, Eyup ^{[1
]}

Erdemli, Mehmet Erman ^{[2
]}

Gul, Mehmet ^{[3
]}

Erdemli, Zeynep ^{[1
]}

Gul, Semir ^{[3
]}

Turkoz, Yusuf ^{[1
]}

机构：

[1] Karabuk Univ, Tip Fak, Med Biochem, TR-78050 Karabuk, Turkey

[2] Inonu Univ, Med Biochem, Tip Fak, Malatya, Turkey

[3] Inonu Univ, Histol, Tip Fak, Malatya, Turkey

来源：

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY | 2021年 / 103卷 / 02期

关键词：

Tartrazine; crocin; oxidative stress; malondialdehyde; ileum; colon; OXIDATIVE STRESS; ISCHEMIA-REPERFUSION; SAFFRON EXTRACT; DYE TARTRAZINE; SATIVUS L; AZO-DYE; ANTIOXIDANT; PROTECTS; CONSTITUENTS; MEMORY;

D O I：

10.1080/02772248.2021.1942472

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tartrazine is used in the pharmaceutical, cosmetic, and food industries worldwide, despite its many toxic effects. The therapeutic effects of crocin (50mg/kg/day) against tartrazine-induced (500mg/kg/day) oxidative damage in ileum and colon tissues in rats have been investigated. Malondialdehyde and total oxidant status levels elevated by tartrazine within the ileum and colon tissues were reduced with crocin treatment, while tartrazine decreased antioxidative parameters (glutathione, total antioxidant status, superoxide dismutase, and catalase) were reverted. Tartrazine-induced histopathological changes of ileum and colon tissues were ameliorated following crocin treatment. In conclusion, Tartrazine consumption elicited tissue injury via lipid peroxidation, and crocin ameliorated oxidative injury by its antioxidant and free radical scavenger properties.

引用

页码：184 / 198

页数：15

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