The physiological roles of Sirt1 in skeletal muscle

被引：66

作者：

Pardo, Patricia S. ^{[1
]}

Boriek, Aladin M. ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Med, Div Pulm Crit Care & Sleep, Houston, TX 77030 USA

来源：

AGING-US | 2011年 / 3卷 / 04期

关键词：

aging; sirtuins; SIRT1; skeletal muscle; differentiation; nutrients; DNA-DELETION MUTATIONS; SATELLITE CELLS; MITOCHONDRIAL-FUNCTION; TRANSCRIPTION FACTORS; OXIDATIVE STRESS; ACTIVATING SIRT1; COACTIVATOR; EXERCISE; AMPK; GENE;

D O I：

10.18632/aging.100312

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Skeletal muscle aging is associated with increased inflammation and oxidative stress, a decrease in the ability to rebuild muscle after injury and in response to exercise. In this perspective, we discuss the mechanisms regulating Sirt1 activity and expression in skeletal muscles, emphasizing their implications in muscle physiology and the impairment of muscle function with age.

引用

页码：430 / 437

页数：8

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