In Vitro Study of Temperature and pH-Responsive Gentamycin Sulphate-Loaded Chitosan-Based Hydrogel Films for Wound Dressing Applications

被引：16
作者：
Qureshi, Mohammad Amir [1 ]
Khatoon, Fehmeeda [1 ]
机构：
[1] Jamia Millia Islamia, Fac Engn & Technol, Dept Appl Sci & Humanities, New Delhi 110025, India
来源：
POLYMER-PLASTICS TECHNOLOGY AND ENGINEERING | 2015年 / 54卷 / 06期
关键词：
Chitosan; Gentamycin sulphate; Glycerol; Poly vinyl pyrolidone; Poly (N-isopropyl acrylamide); NETWORK HYDROGELS; POLYMER BRUSHES; DRUG-DELIVERY; RELEASE; SYSTEM;
D O I：
10.1080/03602559.2014.974186
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Developments in the field of polymer science have led us to the development of Chitosan and PNIPAm mixed pH and temperature responsive hydrogel films. Characterizations were done by Swelling analysis, FTIR, DSC, FESEM and Antibacterial assay. Optimized hydrogel film on swelling analysis does not lose its shape and was not dissolve in to the different buffer solution and at different temperature. FTIR, DSC and FESEM study confirmed the changes in to the hydrogel film after drug absorption. On increasing the temperature and change in pH of the solution, drug absorption increased which was confirmed by zone of inhibition against E. coli.
引用
收藏
页码：573 / 580
页数：8
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