Crassicauline A/β-cyclodextrin host-guest system: Preparation, characterization, inclusion mode, solubilization and stability

被引：52
作者：
Chen, Wen [1 ,2 ]
Yang, Li-Juan [1 ,2 ,3 ]
Ma, Shui-Xian [1 ,2 ]
Yang, Xiao-Dong [3 ]
Fan, Bao-Min [1 ,2 ]
Lin, Jun [3 ]
机构：
[1] Yunnan Univ Nationalities, State Ethn Affairs Commiss, Key Lab Ethn Med Resource Chem, Kunming 650031, Peoples R China
[2] Yunnan Univ Nationalities, Minist Educ, Sch Chem & Biotechnol, Kunming 650031, Peoples R China
[3] Yunnan Univ, Minist Educ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2011年 / 84卷 / 04期
关键词：
Crassicauline A; beta-Cyclodextrin; Inclusion complex; Solubilization; Stability; BETA-CYCLODEXTRIN; NORDITERPENOID ALKALOIDS; BRIDGED BIS(BETA-CYCLODEXTRIN)S; COMPLEXES; BINDING; AZADIRACHTIN; DERIVATIVES; BEHAVIORS;
D O I：
10.1016/j.carbpol.2011.01.031
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The inclusion complexation behavior, characterization and binding ability of crassicauline A (CLA) with beta-cyclodextrin (beta-CD) has been investigated in both solution and the solid state by means of UV-vis spectroscopy, FT-IR, H-1 and 2D NMR, XRD, SEM and DSC. The results showed that the water solubility and thermal stability of CLA were obviously increased in the inclusion complex with beta-CD. This satisfactory water solubility and high stability of the CLA/beta-CD complex will be potentially useful for its application as herbal medicine or healthcare products. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1321 / 1328
页数：8
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