Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT-mediated NAD biosynthesis

被引：88

作者：

Imai, Shin-ichiro ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

来源：

FEBS LETTERS | 2011年 / 585卷 / 11期

关键词：

Aging; Longevity; SIRT1; NAMPT; NAD biosynthesis; NAD World; STIMULATED INSULIN-SECRETION; CIRCADIAN CONTROL; ADIPOSE-TISSUE; BETA-CELLS; GLUCOSE; MICE; RESTRICTION; SIRTUINS; PATHWAY; COMPLEX;

D O I：

10.1016/j.febslet.2011.04.060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Many countries are facing social and economic problems due to increased elderly demographics. With these demands, it is now critical to understand the fundamental regulatory mechanism for aging and longevity in mammals. Our studies on the mammalian NAD-dependent deacetylase SIRT1 and nicotinamide phosphoribosyltransferase (NAMPT)-mediated systemic NAD biosynthesis led us to propose a comprehensive model for the systemic regulatory network connecting metabolism and aging, termed the "NAD World". In this article, I will discuss the importance of SIRT1 and NAMPT-mediated NAD biosynthesis in the NAD World and the system dynamics of this hierarchical network for the connection between metabolism and aging. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1657 / 1662

页数：6

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