Nasopharyngeal Carriage of Individual Streptococcus pneumoniae Serotypes During Pediatric Pneumonia as a Means to Estimate Serotype Disease Potential

被引:76
作者
Greenberg, David [1 ]
Givon-Lavi, Noga [1 ]
Newman, Nitza [2 ]
Bar-Ziv, Jacob [3 ]
Dagan, Ron [1 ]
机构
[1] Ben Gurion Univ Negev, Pediat Infect Dis Unit, Soroka Univ Med Ctr, IL-84105 Beer Sheva, Israel
[2] Ben Gurion Univ Negev, Dept Pediat Surg, Soroka Univ Med Ctr, IL-84105 Beer Sheva, Israel
[3] Hadassah Univ Med Ctr, Dept Radiol, Jerusalem, Israel
关键词
community-acquired pneumonia; children; chest x-ray; clinical; laboratory characteristics; PNEUMOCOCCAL CONJUGATE VACCINE; ACUTE OTITIS-MEDIA; INVASIVE-DISEASE; PARAPNEUMONIC EMPYEMA; CHILDREN; IMPACT; POPULATION; EMERGENCE; DURATION; 7-VALENT;
D O I
10.1097/INF.0b013e3181f87802
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: We aimed at estimating pneumococcal serotype-specific disease potential in pediatric community-acquired alveolar pneumonia (CAAP), by comparing nasopharyngeal pneumococcal carriage during disease to carriage in healthy children. Methods: Pneumococcal nasopharyngeal cultures were obtained from children <5 years old admitted to the emergency room or hospitalized with radiologically diagnosed CAAP and from healthy controls. Disease potential was estimated by calculating serotype-specific odds ratios (OR) of a given serotype to be carried during disease compared with healthy children (after adjustment for age, ethnicity, previous antibiotic therapy, and season). Results: A total of 603 and 1504 isolates were obtained from CAAP and healthy children, respectively. A significant OR >1.0 of a specific serotype being carried during disease (suggesting a higher disease potential) was observed with serotypes (by decreasing rank) 1, 5, 22F, 7F, 14, 9V, and 19A. A significant OR <1.0 of being carried during disease (suggesting a lower disease potential) was observed with serotypes 6A, 6B, 23A, and 35B. Carriage of PCV7 serotypes (grouped) during CAAP was highest in age group 6 to 17 months. PCV10 and PCV13 provided significantly higher coverage for both 6 to 17 and 18 to 35 month age groups. Conclusions: It is suggested that serotypes 1, 5, 7F, 9V, 14, 19A, and 22F have a higher disease potential for childhood pneumonia than do serotypes 6A, 6B, 23A, and 35B.
引用
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页码:227 / 233
页数:7
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