Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels -: Nanogel composed of poly[2-(N,N-diethylamino)ethyl methacrylate] core and PEG tethered chains

被引：51

作者：

Oishi, Motoi

Nagasaki, Yukio

机构：

[1] Univ Tsukuba, Grad Sch Comprehens Human, Tsukuba Res Ctr Interdisciplin Mat Sci, Tsukuba, Ibaraki 3058573, Japan

[2] Univ Tsukuba, Grad Sch Comprehens Human, Ctr Tsukuba Adv res Alliance, Tsukuba, Ibaraki 3058573, Japan

[3] Univ Tsukuba, Grad Sch Pure & Appl Sci, Dept Mat Sci, Tsukuba, Ibaraki 3058573, Japan

[4] Univ Tsukuba, Grad Sch Comprehens Human, Masters Sch Med Sci, Tsukuba, Ibaraki 3058573, Japan

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2007年 / 67卷 / 11期

关键词：

stimuli-responsive nanoparticle; PEGylated nanogel; drug and gene delivery system; nanoreactor; nanocatalyst;

D O I：

10.1016/j.reactfunctpolym.2007.07.009

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We present a review of stimuli-responsive smart PEGylated nanogels and their biomedical applications. We describe the synthesis and characterization of stimuli-responsive PEGylated nanogels composed of a cross-linked poly[2-(N,N-diethylamino)ethyl methacrylate] (PDEAMA) core and PEG tethered chains that bear a carboxylic acid group as a platform moiety for the installation of bio-tags. In addition, PEGylated nanogels show unique properties and functions in synchronizing with the reversible volume phase transition of the PDEAMA core in response to various stimuli, such as pH, ionic strength and temperature. We list some of the biomedical applications of the nanogels, including endosomolytic agents for nonviral gene delivery, drug delivery carriers, nanoreactors, and skin-specific nanocatalysts for reactive oxygen species (ROS). (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1311 / 1329

页数：19

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