Role of Exosomes in Brain Diseases

被引：26
作者：
Zhang, Nan [1 ]
He, Fengling [1 ]
Li, Ting [1 ]
Chen, Jinzhi [1 ]
Jiang, Liping [1 ,2 ]
Ouyang, Xin-Ping [1 ,3 ]
Zuo, Lielian [1 ]
机构：
[1] Univ South China, Hengyang Key Lab Neurodegenerat & Cognit Impairme, Dept Physiol, Hengyang Med Sch,Inst Neurosci Res, Hengyang, Peoples R China
[2] Hunan Taihe Hosp, Changsha, Peoples R China
[3] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Peoples R China
来源：
FRONTIERS IN CELLULAR NEUROSCIENCE | 2021年 / 15卷
基金：
中国国家自然科学基金;
关键词：
clinical treatment; biomarkers; cargo; brain diseases; exosomes; miRNAs; ALPHA-SYNUCLEIN; EXTRACELLULAR VESICLES; RNA EXPRESSION; MICRORNAS; CELLS; DELIVERY; STROKE; SERUM; TAU; COMMUNICATION;
D O I：
10.3389/fncel.2021.743353
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Exosomes are a subset of extracellular vesicles that act as messengers to facilitate communication between cells. Non-coding RNAs, proteins, lipids, and microRNAs are delivered by the exosomes to target molecules (such as proteins, mRNAs, or DNA) of host cells, thereby playing a key role in the maintenance of normal brain function. However, exosomes are also involved in the occurrence, prognosis, and clinical treatment of brain diseases, such as Alzheimer's disease, Parkinson's disease, stroke, and traumatic brain injury. In this review, we have summarized novel findings that elucidate the role of exosomes in the occurrence, prognosis, and treatment of brain diseases.
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页数：14
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