A pectic polysaccharide from Ligusticum chuanxiong promotes intestine antioxidant defense in aged mice

被引：63

作者：

Huang, Chao ^{[1
,3
]}

Cao, Xiyue ^{[1
,3
]}

Chen, Xingfu ^{[5
]}

Fu, Yuping ^{[2
,3
]}

Zhu, Yingguo ^{[4
]}

Chen, Zhengli ^{[1
,3
]}

Luo, Qihui ^{[1
,3
]}

Li, Lixia ^{[2
,3
]}

Song, Xu ^{[2
,3
]}

Jia, Renyong ^{[3
]}

Yin, Zhongqiong ^{[2
,3
]}

Feng, Bin ^{[4
]}

Zou, Yuanfeng ^{[2
,3
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Lab Expt Anim Dis Model, Chengdu 611130, Sichuan, Peoples R China

[2] Sichuan Agr Univ, Coll Vet Med, Nat Med Res Ctr, Chengdu 611130, Sichuan, Peoples R China

[3] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu 611130, Sichuan, Peoples R China

[4] Sichuan Agr Univ, Anim Inst Nutr, Chengdu 611130, Sichuan, Peoples R China

[5] Sichuan Agr Univ, Coll Agron, Minist Agr, Key Lab Crop Ecophysiol & Farming Syst Southwest, Chengdu 611130, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2017年 / 174卷

基金：

中国国家自然科学基金;

关键词：

Ligusticum chuanxiong; Pectic polysaccharide; Intestine; Oxidative stress; Antioxidant defense; OXIDATIVE STRESS; STRUCTURAL-CHARACTERIZATION; NEURODEGENERATION; EXTRACTION; RADICALS; DISEASES; RHIZOME; BIOLOGY; HORT;

D O I：

10.1016/j.carbpol.2017.06.122

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The extensive prospects of polysaccharides in medicine and pharmaceuticals have elicited much interest. Ligusticum chuanxiong polysaccharides, previously extracted as neutral polysaccharides, exhibit antioxidant, anticancer, andantibacterial capacities in vitro. Here we show one pectic polysaccharide extracted from rhizome of L. chuanxiong(LCP-II-I). Structural analysis indicated its long homogalacturonan region is interrupted by rhamnogalacturonan type I, with arabinan and arabinogalactan type I as side chains. Intake of the LCP-II-I significantly promoted the expression of antioxidant enzymes and their master regulator PGC-1 alpha, resulting in higher antioxidant capacity in jejunum and cecum of aged mice. Consistently, treatment with LCP-II-I promotes antioxidant enzymes expression, and protects SW480 cells against H2O2 induced oxidative stress. Our work isolates and identifies a pectic polysaccharide, LCP-II-I, and reveals its potential application in antioxidant defense, which will be important for oxidative stress related disorders treatment in aging intestine. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：915 / 922

页数：8

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