Long Noncoding RNAs and MicroRNAs in Cardiovascular Pathophysiology

被引：333
|
作者：
Thum, Thomas [1 ,2 ]
Condorelli, Gianluigi [3 ,4 ,5 ,6 ]
机构：
[1] Hannover Med Sch, IMTTS, Integrated Res & Treatment Ctr, Transplantat & REBIRTH Excellence Cluster, D-30625 Hannover, Germany
[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
[3] Humanitas Clin & Res Ctr, Milan, Italy
[4] Natl Res Country Italy, Inst Genet & Biomed Res, Milan, Italy
[5] Univ Milan, Milan, Italy
[6] Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England
来源：
CIRCULATION RESEARCH | 2015年 / 116卷 / 04期
基金：
欧洲研究理事会;
关键词：
cardiac hypertrophy; cardiac remodelling; heart failure; lncRNAs; microRNAs; myocardial infarction; SYSTEMIC ENERGY HOMEOSTASIS; MYOCARDIAL-INFARCTION; HEART-FAILURE; CARDIAC-HYPERTROPHY; GENE-EXPRESSION; ENDOTHELIAL-CELLS; CIRCULATING MICRORNAS; MULTIVESICULAR BODIES; X-INACTIVATION; FAILING HEART;
D O I：
10.1161/CIRCRESAHA.116.303549
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
RNAs not encoding proteins have gained prominence over the last couple of decades as fundamental regulators of cellular function. Not surprisingly, their dysregulation is increasingly being linked to pathology. Here, we review recent reports investigating the pathophysiological relevance of this species of RNA for the cardiovascular system, concentrating mainly on recent findings on long noncoding RNAs and microRNAs in cardiac hypertrophy and failure.
引用
收藏
页码：751 / 762
页数：12
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