Combination of contrast-enhanced ultrasound and strain elastography to assess cytologically non-diagnostic thyroid nodules

被引:12
作者
Lin, Zi-Mei [1 ]
Wen, Qing [1 ]
Yan, Cao-Xin [1 ]
Pan, Min-Qiang [1 ]
Mo, Guo-Qiang [1 ]
Chen, Ji-Fan [1 ]
Huang, Pin-Tong [1 ]
机构
[1] Zhejiang Univ, Affiliated Hosp 2, Dept Ultrasound, Sch Med, 88 Jiefang Rd, Hangzhou 310009, Zhejiang, Peoples R China
基金
中国国家自然科学基金;
关键词
contrast-enhanced ultrasound; fine-needle aspiration; thyroid nodule; ultrasound; strain elastography; NEEDLE-ASPIRATION BIOPSY; DIFFERENTIAL-DIAGNOSIS; DATA SYSTEM; CANCER; TIME; ELASTOSONOGRAPHY; INDETERMINATE; MANAGEMENT; BENIGN;
D O I
10.3892/ol.2019.11058
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The aim of the present study was to investigate the benefits of combining contrast-enhanced ultrasound (CEUS) and strain elastography (SE) for the diagnosis of thyroid nodules with non-diagnostic fine-needle aspiration cytology (FNAC) results. Between October 2013 and March 2017, CEUS and SE were performed in 226 patients (236 thyroid nodules) with non-diagnostic FNAC results prior to thyroidectomy. The diagnostic value of CEUS, SE and their combination (CEUS+SE) in distinguishing malignant from benign thyroid nodules was evaluated, using surgical pathology as a reference. Receiver operating characteristic curve analysis was used to assess the diagnostic performance of CEUS, SE and CEUS+SE in determining malignant thyroid nodules. Subsequently, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of CEUS, SE and CEUS + SE were calculated. The malignancy rate in patients with thyroid nodules and non-diagnostic FNAC results was 26.3% in the present study. The sensitivity, specificity, PPV, NPV, accuracy and area under the curve in predicting malignant thyroid nodules were 80.6, 85.6, 66.7, 92.5, 84.3 and 0.831%, respectively, using SE alone; 59.7, 95.9, 84.1, 86.9, 86.4 and 0.778%, respectively, using CEUS alone; and 83.9, 89.1, 73.6, 94.5, 88.1 and 0.865%, respectively, using the combination of CEUS and SE. Overall, the combination of CEUS with SE resulted in higher sensitivity, NPV and accuracy in the diagnosis of cytologically non-diagnostic thyroid nodules compared with CEUS or SE alone.
引用
收藏
页码:6845 / 6851
页数:7
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