Systemic hemodynamic and left ventricular function of diabetic-induced hypertensive rats

被引：5
作者：
Ribeiro Cesaretti, Mario Luis [1 ,2 ]
Ginoza, Milton [1 ]
Ribeiro, Artur Beltrame [1 ]
Kohlmann, Osvaldo, Jr. [1 ]
机构：
[1] Univ Fed Sao Paulo, Disciplina Nefrol, BR-04023900 Sao Paulo, Brazil
[2] Pontificia Univ Catolica Sao Paulo PUC SP, Dept Ciencias Fisiol, Sao Paulo, Brazil
来源：
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2010年 / 54卷 / 09期
关键词：
Diabetes mellitus; experimental; hypertrophy; left ventricular; ventricular function; left; hemodynamics; BLOOD-PRESSURE; CARDIAC-FUNCTION; STREPTOZOTOCIN; CARDIOMYOPATHY; NEPHROPATHY; DISEASE; HEART;
D O I：
10.1590/S0004-27302010000900011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To analyze the effects of type-1 diabetes mellitus (DM1) induction on systemic hennodynamic and ventricular function of normotensive and hypertensive rats. Materials and methods: DM1 was induced by streptozotocin in Wistar rats (WST), borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR). The systemic hemodynamic was evaluated by thermodilution and ventricular function by Langendorff preparation. Results: DM1-induction increased tail arterial pressure of WST and BHR. DM1 also increased total peripheral resistance in WST and decrease in cardiac output stroke volume in WST and BHR. Systolic function indexes were reduced and ventricular stiffness increased in all WST-diabetic rats. All of these effects were more prominent on diabetic WST rats. Conclusion: The DM1 in rats was accompanied by important changes in both systolic and diastolic heart function leading to significant changes in the systemic hemodynamics that were not significantly enhanced by hypertension. Arq Bras Endocrinol Metab. 2010;54(9):842-51
引用
收藏
页码：842 / 851
页数：10
相关论文
共 50 条
  • [21] Changes in plasma prekallikrein activity, blood pressure, and left ventricular thickness in hypertensive and normotensive diabetic rats
    Sharma, J. N.
    Kesavarao, U.
    METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, 2007, 29 (02): : 75 - 78
  • [22] Atorvastatin ameliorates cardiac fibrosis and improves left ventricular diastolic function in hypertensive diastolic heart failure model rats
    Akahori, Hirokuni
    Tsujino, Takeshi
    Naito, Yoshiro
    Matsumoto, Mika
    Sasaki, Naoko
    Iwasaku, Toshihiro
    Eguchi, Akiyo
    Sawada, Hisashi
    Hirotani, Shinichi
    Masuyama, Tohru
    JOURNAL OF HYPERTENSION, 2014, 32 (07) : 1534 - 1541
  • [23] Metformin Improves Cardiac Metabolism and Function, and Prevents Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats
    Li, Jie
    Minczuk, Krzysztof
    Massey, James C.
    Howell, Nancy L.
    Roy, R. Jack
    Paul, Soumen
    Patrie, James T.
    Kramer, Christopher M.
    Epstein, Frederick H.
    Carey, Robert M.
    Taegtmeyer, Heinrich
    Keller, Susanna R.
    Kundu, Bijoy K.
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2020, 9 (07):
  • [24] Protective Effects of Chromium Picolinate Against Diabetic-Induced Renal Dysfunction and Renal Fibrosis in Streptozotocin-Induced Diabetic Rats
    Qi, Shan Shan
    Zheng, Hong Xing
    Jiang, Hai
    Yuan, Li Ping
    Dong, Le Chen
    BIOMOLECULES, 2020, 10 (03)
  • [25] Hypertensive heart disease: Benefit of carvedilol in hemodynamic, left ventricular remodeling, and survival
    Dominguez, Renata F.
    da Costa-Hong, Valeria A.
    Ferretti, Luan
    Fernandes, Fabio
    Bortolotto, Luiz A.
    Consolim-Colombo, Fernanda M.
    Egan, Brent M.
    Lopes, Heno F.
    SAGE OPEN MEDICINE, 2019, 7
  • [26] Dantrolene improves left ventricular diastolic property in mineralcorticoid-salt-induced hypertensive rats
    Nawata, Junya
    Yamamoto, Takeshi
    Tanaka, Shinji
    Yano, Yasutake
    Uchida, Tomoyuki
    Fujii, Shohei
    Nakamura, Yoshihide
    Suetomi, Takeshi
    Uchinoumi, Hitoshi
    Oda, Tetsuro
    Kobayashi, Shigeki
    Yano, Masafumi
    BIOCHEMISTRY AND BIOPHYSICS REPORTS, 2023, 34
  • [27] Plasma Glucose Levels and Left Ventricular Diastolic Function in Nondiabetic Hypertensive Patients
    Catena, Cristiana
    Colussi, GianLuca
    Martinis, Flavia
    Pezzutto, Francesca
    Sechi, Leonardo A.
    AMERICAN JOURNAL OF HYPERTENSION, 2013, 26 (11) : 1353 - 1361
  • [28] Abnormal regional left ventricular mechanics in treated hypertensive patients with 'normal left ventricular function'
    Xiao, Han B.
    Kaleem, Shahla
    McCarthy, Carolyn
    Rosen, Stuart D.
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2006, 112 (03) : 316 - 321
  • [29] Atorvastatin Prevents Left Ventricular Remodeling in Spontaneously Hypertensive Rats
    Zhao, Xiao-yan
    Li, Ling
    Zhang, Jin-ying
    Liu, Gang-qiong
    Chen, Ya-li
    Yang, Pei-ling
    Liu, Rui-yun
    INTERNATIONAL HEART JOURNAL, 2010, 51 (06) : 426 - 431
  • [30] Effects of Insuline on Oxidative Stress and Free Fatty Acid Level in Left Ventricular Muscles of Diabetic Rats
    Kavak, Servet
    Ayaz, Lokman
    Emre, Mustafa
    Bozkurt, Abdi
    ASIAN JOURNAL OF CHEMISTRY, 2009, 21 (07) : 5677 - 5684
12345