Systemic hemodynamic and left ventricular function of diabetic-induced hypertensive rats

被引：5
作者：
Ribeiro Cesaretti, Mario Luis [1 ,2 ]
Ginoza, Milton [1 ]
Ribeiro, Artur Beltrame [1 ]
Kohlmann, Osvaldo, Jr. [1 ]
机构：
[1] Univ Fed Sao Paulo, Disciplina Nefrol, BR-04023900 Sao Paulo, Brazil
[2] Pontificia Univ Catolica Sao Paulo PUC SP, Dept Ciencias Fisiol, Sao Paulo, Brazil
来源：
ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA | 2010年 / 54卷 / 09期
关键词：
Diabetes mellitus; experimental; hypertrophy; left ventricular; ventricular function; left; hemodynamics; BLOOD-PRESSURE; CARDIAC-FUNCTION; STREPTOZOTOCIN; CARDIOMYOPATHY; NEPHROPATHY; DISEASE; HEART;
D O I：
10.1590/S0004-27302010000900011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective: To analyze the effects of type-1 diabetes mellitus (DM1) induction on systemic hennodynamic and ventricular function of normotensive and hypertensive rats. Materials and methods: DM1 was induced by streptozotocin in Wistar rats (WST), borderline hypertensive rats (BHR) and spontaneously hypertensive rats (SHR). The systemic hemodynamic was evaluated by thermodilution and ventricular function by Langendorff preparation. Results: DM1-induction increased tail arterial pressure of WST and BHR. DM1 also increased total peripheral resistance in WST and decrease in cardiac output stroke volume in WST and BHR. Systolic function indexes were reduced and ventricular stiffness increased in all WST-diabetic rats. All of these effects were more prominent on diabetic WST rats. Conclusion: The DM1 in rats was accompanied by important changes in both systolic and diastolic heart function leading to significant changes in the systemic hemodynamics that were not significantly enhanced by hypertension. Arq Bras Endocrinol Metab. 2010;54(9):842-51
引用
收藏
页码：842 / 851
页数：10
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