Circulating tumour cells and circulating nucleic acids as a measure of tumour dissemination in non-metastatic colorectal cancer surgery

被引：11
作者：
Lim, S. H. [1 ,2 ,3 ,4 ]
Spring, K. J. [1 ,4 ,5 ]
de Souza, P. [1 ,2 ,3 ,4 ,5 ]
MacKenzie, S. [4 ,5 ,6 ]
Bokey, L. [4 ,5 ,6 ]
机构：
[1] Ingham Inst Appl Med Res, Med Oncol Grp, Liverpool, NSW 2170, Australia
[2] Liverpool Hosp, Dept Med Oncol, Liverpool 2170, Australia
[3] Univ New S Wales, Sch Med, Kensington, NSW 2052, Australia
[4] Ctr Oncol Educ & Res Translat CONCERT, Liverpool 2170, Australia
[5] Univ Western Sydney, Liverpool Clin Sch, Liverpool 2170, Australia
[6] Liverpool Hosp, Dept Colorectal Surg, Sydney, NSW 2170, Australia
来源：
EJSO | 2015年 / 41卷 / 03期
关键词：
Circulating tumour cells; Tumour dissemination; Colorectal cancer; Surgery; MOLECULAR-DETECTION; FOLLOW-UP; PERIPHERAL-BLOOD; CLINICAL-USE; SERUM; RECURRENCE; METHYLATION; CARCINOMAS; BIOMARKERS; RESECTION;
D O I：
10.1016/j.ejso.2014.12.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
There is accumulating evidence for circulating tumour cells (CTCs) and circulating tumour nucleic acids (ctNAs) as prognostic and predictive biomarkers in colorectal cancer. Their role in the perioperative setting is evolving. These blood-borne biomarkers can potentially demonstrate tumour dissemination at time of colorectal cancer surgery and estimate the completeness of a surgical resection. CTCs and circulating ctNA levels at time of surgery, and persistent levels post-surgery, may correlate with poorer patient outcomes. These biomarkers can be utilised to refine surgical techniques to minimise tumour dissemination and determine the need for adjuvant therapy. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：309 / 314
页数：6
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