Chemotherapy alone in laryngeal squamous cell carcinoma

被引：11
作者：
Bonfils, P. [1 ]
Trotoux, J. [1 ]
Bassot, V. [1 ]
机构：
[1] Univ Paris 05, Dept Otorhinolaryngol Head & Neck Surg, Hop Europeen Georges Pompidou, Fac Med, F-75015 Paris, France
来源：
JOURNAL OF LARYNGOLOGY AND OTOLOGY | 2007年 / 121卷 / 02期
关键词：
larynx neoplasms; carcinoma; squamous cell; antineoplastic agents;
D O I：
10.1017/S0022215106003173
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Aims: To evaluate the results of chemotherapy alone in patients with invasive squamous cell carcinoma of the larynx who have achieved a complete clinical response after an induction chemotherapy protocol. Methods: A comparison of results in a group of complete responders managed with a chemotherapy alone protocol, matched with those of an incomplete responder group managed with conventional modalities. Results: The survival rate of the complete responder group was significantly higher than that of the incomplete responder group. No statistically significant difference was noted between the two groups in terms of local failure and nodal recurrence. Conclusion: Our results confirm the fact that chemotherapy alone is a viable option in selected patients with carcinoma of the larynx who have achieved a complete clinical response after an induction chemotherapy protocol. This therapeutic approach allows surgery and/or radiation therapy to be reserved for the management of metachronous second primary tumours.
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收藏
页码：143 / 148
页数：6
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