Intake compensates for resting metabolic rate variation in female C57BL/6J mice fed high-fat diets

被引:39
作者
Johnston, Sarah L.
Souter, Donna M.
Tolkamp, Bert J.
Gordon, Iain J.
Illius, Andrew W.
Kyriazakis, Ilias
Speakman, John R. [1 ]
机构
[1] Univ Auckland, Dept Nutr, Auckland 1, New Zealand
[2] Univ Aberdeen, Sch Biol Sci, Aberdeen AB24 2TZ, Scotland
[3] Rowett Res Inst, Obes & Metab Hlth Div, Bucksburn, Aberdeen, Scotland
[4] Scottish Agr Coll, Anim Nutr & Hlth Dept, Edinburgh, Midlothian, Scotland
[5] Univ Edinburgh, Sch Biol Sci, Inst Evolut Biol, Edinburgh, Midlothian, Scotland
[6] Univ Aberdeen, Aberdeen Ctr Energy Balance & Obes, Sch Biol Sci, Aberdeen, Scotland
关键词
high-fat diet; fat mass; DXA; mouse models;
D O I
10.1038/oby.2007.550
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective: The literature is divided over whether variation in resting metabolic rate (RMR) is related to subsequent obesity. We set out to see whether the effect of RMR on weight gain in mice could be revealed with high-fat feeding. Research Methods and Procedures: Female C57BL/6J mice received a low- (10 kcal%fat n = 47), medium- (45 kcal%fat n = 50), or high-fat diet (60 kcal%fat n = 50) for 12 weeks. Pre-treatment RMR was measured by indirect calorimetry. Body composition was estimated using DXA before and after treatment. Results: Mice on the high-fat diet gained 39% of body mass, whereas control animals gained 3.5%. There was no interaction between RMR and dietary type on weight gain, and there was no association between weight gain and RMR for any of the treatments. RMR accounted for 2.4% of the variation in pre-treatment food intake corrected for initial body mass; however, the gradient of this relationship indicated that variations in RMR were, on average, compensated for by adjustments in food intake. Discussion: Individual variations in RMR did not predispose mice to weight gain independent of the dietary treatment. Deviations from the relationship between RMR and food intake were not associated with weight gain. This suggests that variations in energy expenditure, caused by RMR and physical activity, are closely linked to dietary intake, and, therefore, well compensated. Individual variations in the strength of this association may underpin individual variability in the responses to diet.
引用
收藏
页码:600 / 606
页数:7
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